塞拉菌素：一种用于犬猫的新型广谱体内外寄生虫杀虫剂。

Selamectin: a novel broad-spectrum endectocide for dogs and cats.

作者信息

Bishop B F, Bruce C I, Evans N A, Goudie A C, Gration K A, Gibson S P, Pacey M S, Perry D A, Walshe N D, Witty M J

机构信息

Animal Health Discovery, Central Research Division, Pfizer Limited, Sandwich, Kent, UK.

出版信息

Vet Parasitol. 2000 Aug 23;91(3-4):163-76. doi: 10.1016/s0304-4017(00)00289-2.

DOI:10.1016/s0304-4017(00)00289-2

PMID:10940519

Abstract

Selamectin, 25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22, 23-dihydro-5-(hydroxyimino)-avermectin B1 monosaccharide, is a novel endectocide with a unique combination of efficacy and safety in dogs and cats following both oral and topical administration. The compound is active against fleas and ticks, intestinal hookworms and ascarids, and immature heartworms. Also it is well tolerated at higher dosages than 22,23-dihydroavermectin B1a (DHAVM) or milbemycin oxime in Collies, which is a breed known to exhibit idiosyncratic sensitivity to avermectins.

摘要

塞拉菌素，即25-环己基-25-去（1-甲基丙基）-5-脱氧-22,23-二氢-5-（羟基亚氨基）阿维菌素B1单糖，是一种新型体内外寄生虫杀虫剂，经口服和局部给药后，在犬猫身上具有疗效与安全性的独特组合。该化合物对跳蚤、蜱虫、肠道钩虫和蛔虫以及未成熟的心丝虫均有活性。此外，在柯利犬中，它在比22,23-二氢阿维菌素B1a（DHAVM）或米尔贝肟更高的剂量下仍具有良好的耐受性，柯利犬是已知对阿维菌素表现出特异敏感性的犬种。