Ritzhaupt L K, Rowan T G, Jones R L, Cracknell V C, Murphy M G, Shanks D J
Veterinary Medicine Clinical Development, Pfizer Global Research and Development, Pfizer Inc., Eastern Point Road, Mailstop 8200-40, Groton, CT 06340, USA.
Vet Parasitol. 2002 Jun 3;106(2):165-75. doi: 10.1016/s0304-4017(02)00051-1.
The comparative efficacy of monthly administration of selamectin or lufenuron against Ctenocephalides felis felis on dogs and cats was evaluated over a 5-month period in flea-infested environments. Twenty-four dogs and 32 cats were randomly allocated to receiving a topical treatment with selamectin or an oral administration of tablets containing lufenuron/milbemycin oxime (for dogs) or lufenuron only (for cats). Each product was administered in accordance with the manufacturer's label recommendations. Eight dogs and four cats served as untreated sentinels. Treatments were administered on days 0, 30, 60, 90, and 120. Each animal received an application of 100 fleas on days -28 and -21, and then weekly applications of 20 fleas from days 91 through 147. Flea comb counts were performed on day -6, and every 2 weeks after day 0. From day 29 (dogs) or day 44 (cats) to day 150, geometric mean flea counts for selamectin were < or =0.4. Mean flea counts for animals assigned to treatment with selamectin were significantly lower (P=0.0001) than for animals assigned to treatment with lufenuron at all assessments after day 0.
在跳蚤滋生的环境中，对24只狗和32只猫进行了为期5个月的评估，以比较每月施用一次塞拉菌素或氟虫腈对犬猫栉首蚤指名亚种的效果。24只狗和32只猫被随机分配接受塞拉菌素的局部治疗，或口服含氟虫腈/米尔贝霉素肟（用于狗）或仅含氟虫腈（用于猫）的片剂。每种产品均按照制造商的标签建议给药。8只狗和4只猫作为未治疗的哨兵。在第0、30、60、90和120天进行治疗。每只动物在第-28天和-21天接受100只跳蚤的接种，然后从第91天到147天每周接种20只跳蚤。在第-6天以及第0天之后每2周进行一次跳蚤梳检计数。从第29天（狗）或第44天（猫）到第150天，塞拉菌素的几何平均跳蚤计数≤0.4。在第0天之后的所有评估中，接受塞拉菌素治疗的动物的平均跳蚤计数显著低于（P = 0.0001）接受氟虫腈治疗的动物。
