佛波酯B的不对称合成——第一部分：C(20)-C(38)和C(39)-C(46)亚基的合成美国国立卫生研究院（GM-33328）和美国国家科学基金会提供了资金支持。衷心感谢美国癌症协会授予T.E.S.的博士后奖学金以及美国国家科学基金会授予V.J.C.的博士前奖学金。感谢美国国立卫生研究院BRS共享仪器资助计划1-S10-RR04870和美国国家科学基金会（CHE 88-14019）提供核磁共振设施。 - Suppr

Asymmetric Synthesis of Phorboxazole B-Part I: Synthesis of the C(20)-C(38) and C(39)-C(46) Subunits Financial support was provided by the National Institutes of Health (GM-33328) and the National Science Foundation. An American Cancer Society Postdoctoral Fellowship to T.E.S. and an NSF Predoctoral Fellowship to V.J.C. are gratefully acknowledged. The NIH BRS Shared Instrumentation Grant Program 1-S10-RR04870 and the NSF (CHE 88-14019) are acknowledged for providing NMR facilities.

作者信息

Evans DA, Cee VJ, Smith TE, Fitch DM, Cho PS

机构信息

Department of Chemistry & Chemical Biology Harvard University Cambridge, MA 02138 (USA).

出版信息

Angew Chem Int Ed Engl. 2000 Jul 17;39(14):2533-2536. doi: 10.1002/1521-3773(20000717)39:14<2533::aid-anie2533>3.0.co;2-b.

DOI:10.1002/1521-3773(20000717)39:14<2533::aid-anie2533>3.0.co;2-b

PMID:10941127

Abstract

摘要

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Asymmetric Synthesis of Phorboxazole B-Part I: Synthesis of the C(20)-C(38) and C(39)-C(46) Subunits Financial support was provided by the National Institutes of Health (GM-33328) and the National Science Foundation. An American Cancer Society Postdoctoral Fellowship to T.E.S. and an NSF Predoctoral Fellowship to V.J.C. are gratefully acknowledged. The NIH BRS Shared Instrumentation Grant Program 1-S10-RR04870 and the NSF (CHE 88-14019) are acknowledged for providing NMR facilities.佛波酯B的不对称合成——第一部分：C(20)-C(38)和C(39)-C(46)亚基的合成美国国立卫生研究院（GM-33328）和美国国家科学基金会提供了资金支持。衷心感谢美国癌症协会授予T.E.S.的博士后奖学金以及美国国家科学基金会授予V.J.C.的博士前奖学金。感谢美国国立卫生研究院BRS共享仪器资助计划1-S10-RR04870和美国国家科学基金会（CHE 88-14019）提供核磁共振设施。

Angew Chem Int Ed Engl. 2000 Jul 17;39(14):2533-2536. doi: 10.1002/1521-3773(20000717)39:14<2533::aid-anie2533>3.0.co;2-b.

Asymmetric Synthesis of Phorboxazole B-Part II: Synthesis of the C(1)-C(19) Subunit and Fragment Assembly Financial support has been provided by the National Institutes of Health (GM-33328) and the National Science Foundation. The NIH BRS Shared Instrumentation Grant Program 1-S10-RR04870 and the NSF (CHE 88-14019) are acknowledged for providing NMR facilities.佛波醇酯B的不对称合成 - 第二部分：C(1)-C(19)亚基的合成及片段组装美国国立卫生研究院（GM-33328）和美国国家科学基金会提供了资金支持。感谢美国国立卫生研究院BRS共享仪器资助计划1-S10-RR04870和美国国家科学基金会（CHE 88-14019）提供核磁共振设施。

Angew Chem Int Ed Engl. 2000 Jul 17;39(14):2536-2540. doi: 10.1002/1521-3773(20000717)39:14<2536::aid-anie2536>3.0.co;2-u.

A Designed beta-Hairpin Containing a Natural Hydrophobic Cluster This research was supported by the National Science Foundation (CHE-9820952). J.F.E. was supported by a fellowship from the Ministerio de Educacion y Cultura (Spain) and the Fulbright Commission. The mass spectrometer was purchased in part with a National Science Foundation grant (CHE-9520868), and the NMR spectrometers were purchased in part with a National Institute Of Health grant (1 S10 RR04981). The CD spectrometer and analytical ultracentrifuge are part of the UW Biophysics Instrumentation Facility (NSF BIR-9512577).一种含有天然疏水簇的设计型β-发夹本研究得到了美国国家科学基金会（CHE - 9820952）的支持。J.F.E. 获得了西班牙教育和文化部以及富布赖特委员会的奖学金支持。质谱仪部分由美国国家科学基金会拨款（CHE - 9520868）购置，核磁共振光谱仪部分由美国国立卫生研究院拨款（1 S10 RR04981）购置。圆二色光谱仪和分析型超速离心机是华盛顿大学（UW）生物物理仪器设施（美国国家科学基金会BIR - 9512577）的一部分。

Angew Chem Int Ed Engl. 2000 Jul 3;39(13):2330-2333. doi: 10.1002/1521-3773(20000703)39:13<2330::aid-anie2330>3.0.co;2-c.

A General Catalyst for the Asymmetric Strecker Reaction This work was supported by the NIH (GM-43214). A postdoctoral fellowship to M.S.S. (NIH), and a predoctoral fellowship to P.V. sponsored by Alfred Bader are gratefully acknowledged.不对称施特雷克反应的通用催化剂本研究得到了美国国立卫生研究院（GM-43214）的支持。非常感谢授予M.S.S.的博士后奖学金（美国国立卫生研究院）以及由阿尔弗雷德·巴德赞助授予P.V.的博士前奖学金。

Angew Chem Int Ed Engl. 2000 Apr;39(7):1279-1281. doi: 10.1002/(sici)1521-3773(20000403)39:7<1279::aid-anie1279>3.0.co;2-u.

"Cap-Tag"-Novel Methods for the Rapid Purification of Oligosaccharides Prepared by Automated Solid-Phase Synthesis Financial support from the donors of the Petroleum Research Fund, administered by the ACS (ACS-PRF 34649-G1), Merck (Predoctoral Fellowship for E.R.P.), Boehringer-Ingelheim (Predoctoral Fellowship for E.R.P.), and the NIH (Biotechnology Training Grant for M.C.H.) is gratefully acknowledged. Funding for the MIT-DCIF Inova 501 was provided by the NSF (Award CHE-9808061). Funding for the MIT-DCIF Avance (DPX) 400 was provided by the NIH (Award 1S10RR13886-01). We thank Silicycle (Quebec City, Canada) for the generous gift of fluorous silica gel and isocyanate silica gel scavenger resin. We thank Dr. O. Plante for helpful discussions and help with the automated oligosaccharide synthesizer.“帽式标签”——通过自动化固相合成制备寡糖的快速纯化新方法衷心感谢美国化学学会管理的石油研究基金捐赠者（ACS - PRF 34649 - G1）、默克公司（给E.R.P.的博士前奖学金）、勃林格殷格翰公司（给E.R.P.的博士前奖学金）以及美国国立卫生研究院（给M.C.H.的生物技术培训资助）提供的资金支持。麻省理工学院 - 数字化学成像设施Inova 501的资金由美国国家科学基金会提供（奖项CHE - 9808061）。麻省理工学院 - 数字化学成像设施Avance（DPX）400的资金由美国国立卫生研究院提供（奖项1S10RR13886 - 01）。我们感谢Silicycle公司（加拿大魁北克市）慷慨赠送的氟硅胶和异氰酸酯硅胶清除树脂。我们感谢O. Plante博士提供的有益讨论以及在自动寡糖合成仪方面给予的帮助。

Angew Chem Int Ed Engl. 2001 Dec 3;40(23):4433-4437. doi: 10.1002/1521-3773(20011203)40:23<4433::aid-anie4433>3.0.co;2-8.

Stabilization of a Reactive Cationic Species by Supramolecular Encapsulation Coordination Number Incommensurate Cluster Formation, Part 15. This research was supported by NSF grant CHE-9709621. We gratefully acknowledge Prof. Julie A. Leary and Dr. Ulla Andersen for their assistance with mass spectrometry. We also thank the Miller Foundation for a postdoctoral fellowship to M.Z. and the NIH for a postdoctoral fellowship to J.L.B. Part 14: J. Xide, K. N. Raymond, Angew. Chem. 2000, 112, 2857-2859; Angew. Chem. Int. Ed. 2000, 39, 2745-2747.通过超分子包封稳定反应性阳离子物种：配位数不匹配簇的形成，第15部分。本研究得到美国国家科学基金会（NSF）CHE - 9709621号资助。我们非常感谢朱莉·A·利里教授和乌拉·安德森博士在质谱分析方面提供的帮助。我们还要感谢米勒基金会为M.Z.提供博士后奖学金，以及美国国立卫生研究院（NIH）为J.L.B.提供博士后奖学金。第14部分：J. 西德，K. N. 雷蒙德，《德国应用化学》，2000年，112卷，2857 - 2859页；《德国应用化学》国际版，2000年，39卷，2745 - 2747页。

Angew Chem Int Ed Engl. 2000 Nov 17;39(22):4119-4121. doi: 10.1002/1521-3773(20001117)39:22<4119::aid-anie4119>3.0.co;2-1.

The Spongistatins: Architecturally Complex Natural Products-Part Two: Synthesis of the C(29-51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2 Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, a NIH Postdoctoral Fellowship to C.S.B., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr George T. Furst, Dr. Patrick J. Carroll, and Dr. Rakesh Kohli of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra, respectively.海绵他汀类化合物：结构复杂的天然产物——第二部分：C(29 - 51)亚基的合成、片段组装以及(+)-海绵他汀2的最终合成本研究得到了美国国立卫生研究院（国立癌症研究所）的资助，资助编号为CA - 70329；还给C.S.B.提供了美国国立卫生研究院博士后奖学金，给N.M.提供了日本学术振兴会奖学金，给V.A.D.提供了英国皇家学会富布赖特奖学金。我们还感谢第一制药株式会社和田边制药株式会社提供的资金支持。最后，我们感谢宾夕法尼亚大学光谱服务中心的George T. Furst博士、Patrick J. Carroll博士和Rakesh Kohli博士，他们分别在获取和解释高场核磁共振谱、X射线晶体结构以及质谱方面提供了帮助。

Angew Chem Int Ed Engl. 2001 Jan 5;40(1):196-199.

Toward Fully Synthetic Homogeneous Glycoproteins: A High Mannose Core Containing Glycopeptide Carrying Full H-Type 2 Human Blood Group Specificity This work was supported by the National Institutes of Health (Grant nos.: HL-25848 and CA-28824 (to S.J.D.), and CA-710506 (to K.O.L.)). Postdoctoral fellowship support is gratefully acknowledged by Z.-G.W. (US Army breast cancer grant no.: DAMD17-97-1-7119) and M.V. (NIH grant no.: CA-62948-04). We gratefully acknowledge Dr. George Sukenick of the Sloan-Kettering Institute's NMR core facility for mass spectral and NMR spectroscopic analyses (SKI core grant no.: CA-08748).

Angew Chem Int Ed Engl. 2001 May 4;40(9):1728-1732.

Total Synthesis of Lankacyclinol Generous financial support for this research was provided by the National Institutes of Health (Award no.: GM41560). Additionally, a National Institutes of Health Minority Predoctoral Fellowship (Award no.: GM18547) to G.S.C. is gratefully acknowledged. We also wish to thank Dr. Tsuneaki Hida and Dr. Yoshio Kozai, Takeda Chemical Ltd. (Japan), for providing us with an authentic sample of lankacyclinol as well as copies of the original (1)H NMR spectrum.兰卡环醇的全合成本研究得到了美国国立卫生研究院的慷慨资助（资助编号：GM41560）。此外，还要感谢美国国立卫生研究院授予G.S.C.的少数民族博士前奖学金（资助编号：GM18547）。我们还要感谢日本武田化学有限公司的Tsuneaki Hida博士和Yoshio Kozai博士，他们为我们提供了兰卡环醇的正品样品以及原始氢核磁共振谱的复印件。

Angew Chem Int Ed Engl. 2000 Dec 15;39(24):4612-4615. doi: 10.1002/1521-3773(20001215)39:24<4612::aid-anie4612>3.0.co;2-c.

Nickel(II) Phosphate VSB-5: A Magnetic Nanoporous Hydrogenation Catalyst with 24-Ring Tunnels A.K.C. thanks the Fondation de l'Ecole Normale Supérieure and the Région de l'Ile de France for a Chaire Internationale de Recherche, Blaise Pascal. We also thank the CNRS for financial support and for providing a Poste Rouge for Q.G. and a PICS to the two groups for cooperation. The authors are indebted to D. S. Kim for his support with pore size analysis. We thank the Korean Ministry of Science and Technology (Key Research Program, KK-0005-F0) for supporting this work, and the Korea Science and Engineering Foundation (KOSEF) Fellowship for J.S.C. is gratefully acknowledged. J.S.C. was partially supported by the U.S. Department of Energy under grant DE-FG03-96ER14672. P.M.F. was supported by the National Science Foundation under the MRSEC Program (NSF-DMR-96-32716).磷酸镍（II）VSB - 5：一种具有24环隧道的磁性纳米多孔氢化催化剂 A.K.C.感谢巴黎高等师范学校基金会和法兰西岛大区提供的布莱士·帕斯卡国际研究主席职位。我们还要感谢法国国家科学研究中心的资金支持，以及为Q.G.提供的红色职位和为两个合作团队提供的国际合作项目资助。作者们感谢D.S. Kim在孔径分析方面给予的支持。我们感谢韩国科学技术部（重点研究项目，KK - 0005 - F0）对这项工作的支持，并且感谢韩国科学与工程基金会为J.S.C.提供的奖学金。J.S.C.部分得到了美国能源部授予的DE - FG03 - 96ER14672号资助。P.M.F.得到了美国国家科学基金会在材料研究科学与工程中心项目（NSF - DMR - 96 - 32716）下的支持。

Angew Chem Int Ed Engl. 2001 Aug 3;40(15):2831-2834.

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