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Asymmetric Synthesis of Phorboxazole B-Part II: Synthesis of the C(1)-C(19) Subunit and Fragment Assembly Financial support has been provided by the National Institutes of Health (GM-33328) and the National Science Foundation. The NIH BRS Shared Instrumentation Grant Program 1-S10-RR04870 and the NSF (CHE 88-14019) are acknowledged for providing NMR facilities.

作者信息

Evans DA, Fitch DM

机构信息

Department of Chemistry & Chemical Biology Harvard University Cambridge, MA 02138 (USA).

出版信息

Angew Chem Int Ed Engl. 2000 Jul 17;39(14):2536-2540. doi: 10.1002/1521-3773(20000717)39:14<2536::aid-anie2536>3.0.co;2-u.

DOI:10.1002/1521-3773(20000717)39:14<2536::aid-anie2536>3.0.co;2-u
PMID:10941128
Abstract
摘要

相似文献

1
Asymmetric Synthesis of Phorboxazole B-Part II: Synthesis of the C(1)-C(19) Subunit and Fragment Assembly Financial support has been provided by the National Institutes of Health (GM-33328) and the National Science Foundation. The NIH BRS Shared Instrumentation Grant Program 1-S10-RR04870 and the NSF (CHE 88-14019) are acknowledged for providing NMR facilities.佛波醇酯B的不对称合成 - 第二部分：C(1)-C(19)亚基的合成及片段组装 美国国立卫生研究院（GM-33328）和美国国家科学基金会提供了资金支持。感谢美国国立卫生研究院BRS共享仪器资助计划1-S10-RR04870和美国国家科学基金会（CHE 88-14019）提供核磁共振设施。
Angew Chem Int Ed Engl. 2000 Jul 17;39(14):2536-2540. doi: 10.1002/1521-3773(20000717)39:14<2536::aid-anie2536>3.0.co;2-u.
2
Asymmetric Synthesis of Phorboxazole B-Part I: Synthesis of the C(20)-C(38) and C(39)-C(46) Subunits Financial support was provided by the National Institutes of Health (GM-33328) and the National Science Foundation. An American Cancer Society Postdoctoral Fellowship to T.E.S. and an NSF Predoctoral Fellowship to V.J.C. are gratefully acknowledged. The NIH BRS Shared Instrumentation Grant Program 1-S10-RR04870 and the NSF (CHE 88-14019) are acknowledged for providing NMR facilities.佛波酯B的不对称合成——第一部分：C(20)-C(38)和C(39)-C(46)亚基的合成 美国国立卫生研究院（GM-33328）和美国国家科学基金会提供了资金支持。衷心感谢美国癌症协会授予T.E.S.的博士后奖学金以及美国国家科学基金会授予V.J.C.的博士前奖学金。感谢美国国立卫生研究院BRS共享仪器资助计划1-S10-RR04870和美国国家科学基金会（CHE 88-14019）提供核磁共振设施。
Angew Chem Int Ed Engl. 2000 Jul 17;39(14):2533-2536. doi: 10.1002/1521-3773(20000717)39:14<2533::aid-anie2533>3.0.co;2-b.
3
A Designed beta-Hairpin Containing a Natural Hydrophobic Cluster This research was supported by the National Science Foundation (CHE-9820952). J.F.E. was supported by a fellowship from the Ministerio de Educacion y Cultura (Spain) and the Fulbright Commission. The mass spectrometer was purchased in part with a National Science Foundation grant (CHE-9520868), and the NMR spectrometers were purchased in part with a National Institute Of Health grant (1 S10 RR04981). The CD spectrometer and analytical ultracentrifuge are part of the UW Biophysics Instrumentation Facility (NSF BIR-9512577).一种含有天然疏水簇的设计型β-发夹 本研究得到了美国国家科学基金会（CHE - 9820952）的支持。J.F.E. 获得了西班牙教育和文化部以及富布赖特委员会的奖学金支持。质谱仪部分由美国国家科学基金会拨款（CHE - 9520868）购置，核磁共振光谱仪部分由美国国立卫生研究院拨款（1 S10 RR04981）购置。圆二色光谱仪和分析型超速离心机是华盛顿大学（UW）生物物理仪器设施（美国国家科学基金会BIR - 9512577）的一部分。
Angew Chem Int Ed Engl. 2000 Jul 3;39(13):2330-2333. doi: 10.1002/1521-3773(20000703)39:13<2330::aid-anie2330>3.0.co;2-c.
4
Multicarbocycle Formation Mediated by Arenoporphyrin 1,4-Diradicals: Synthesis of Picenoporphyrins This work was supported by grant CHE-99-04076 from the U.S. National Science Foundation and grant HL-22252 from the U.S. National Institutes of Health. The Bruker SMART 1000 diffractometer was funded in part by NSF Instrumentation grant CHE-98-08259.
Angew Chem Int Ed Engl. 2001 Sep 17;40(18):3439-3441. doi: 10.1002/1521-3773(20010917)40:18<3439::aid-anie3439>3.0.co;2-z.
5
Asymmetric, Stereocontrolled Total Synthesis of Paraherquamide A This work was supported by the NIH (Grant CA 70375). The Japanese Society for the Promotion of Science (JSPS) is acknowledged for providing support to H.T. Mass spectra were obtained on instruments supported by the NIH Shared Instrumentation Grant (GM 49631). We also wish to thank Dr. Timothy Blizzard (Merck & Co.) for providing an authentic sample of natural paraherquamide A. We also wish to acknowledge Dr. Byung H. Lee (Pharmacia-Upjohn Co.) for providing NMR spectra and an authentic specimen of 14-oxoparaherquamide B. We also wish to thank Dr. Alfredo Vazquez for assistance with purification and characterization of synthetic paraherquamide A.对羟基赫曲霉素A的不对称、立体控制全合成 本研究得到了美国国立卫生研究院（拨款号CA 70375）的支持。感谢日本学术振兴会（JSPS）对H.T.的支持。质谱是在由美国国立卫生研究院共享仪器拨款（GM 49631）支持的仪器上获得的。我们还感谢蒂莫西·布莱兹德博士（默克公司）提供天然对羟基赫曲霉素A的真品样品。我们还要感谢李炳焕博士（法玛西亚-普强公司）提供核磁共振谱以及14-氧代对羟基赫曲霉素B的真品标本。我们还要感谢阿尔弗雷多·巴斯克斯博士在合成对羟基赫曲霉素A的纯化和表征方面提供的帮助。
Angew Chem Int Ed Engl. 2000 Jul 17;39(14):2540-2544. doi: 10.1002/1521-3773(20000717)39:14<2540::aid-anie2540>3.0.co;2-r.
6
The Spongistatins: Architecturally Complex Natural Products-Part Two: Synthesis of the C(29-51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2 Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, a NIH Postdoctoral Fellowship to C.S.B., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr George T. Furst, Dr. Patrick J. Carroll, and Dr. Rakesh Kohli of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra, respectively.海绵他汀类化合物：结构复杂的天然产物——第二部分：C(29 - 51)亚基的合成、片段组装以及(+)-海绵他汀2的最终合成 本研究得到了美国国立卫生研究院（国立癌症研究所）的资助，资助编号为CA - 70329；还给C.S.B.提供了美国国立卫生研究院博士后奖学金，给N.M.提供了日本学术振兴会奖学金，给V.A.D.提供了英国皇家学会富布赖特奖学金。我们还感谢第一制药株式会社和田边制药株式会社提供的资金支持。最后，我们感谢宾夕法尼亚大学光谱服务中心的George T. Furst博士、Patrick J. Carroll博士和Rakesh Kohli博士，他们分别在获取和解释高场核磁共振谱、X射线晶体结构以及质谱方面提供了帮助。
Angew Chem Int Ed Engl. 2001 Jan 5;40(1):196-199.
7
Thwarting beta-Hydride Elimination: Capture of the Alkylpalladium Intermediate of an Asymmetric Intramolecular Heck Reaction This research was supported by the National Institutes of Health (grant GM-12389). M.O. thanks the Deutsche Forschungsgemeinschaft (DFG) for an Emmy Noether fellowship (Oe 249/1-1). NMR and mass spectra were determined at the University of California, Irvine with instruments purchased with the assistance of the NSF and NIH shared instrumentation programs. We are grateful to Dr. Joseph W. Ziller and Dr. John Greaves for their assistance with X-ray structure and mass spectrometric analyses.
Angew Chem Int Ed Engl. 2001 Apr 17;40(8):1439-1442.
8
(-)-Rhizochalin is a Dimeric Enantiomorphic (2R)-Sphingolipid: Absolute Configuration of Pseudo-C(2v)-Symmetric Bis-2-amino-3-alkanols by CD We thank Jeff de Ropp and John MacMillan (University of California, Davis) for assistance with the 600 and 400 MHz (1)H NMR spectra, respectively; Gillian Nicholas (University of California, Davis) for measurement of the CD spectra of 7 a, b; Rich Kondrat (University of California, Riverside Mass Spectrometry Facility) for chemical ionization MS; and Carlito Lebrilla and Yongming Xie (University of California, Davis) for matrix-assisted laser desorption/ionization MS. This work was supported by the National Institutes of Health (NIH; grant no. AI 39987). The NMR spectrometers were funded in part by the National Science Foundation (grant no. CHE-9808183; 400 MHz apparatus) and the NIH (grant no. RR11973; 600 MHz apparatus). CD=circular dichroism.（-）-根赤壳菌素是一种二聚体对映体形式的（2R）-鞘脂：通过圆二色性确定伪C（2v）对称双-2-氨基-3-链烷醇的绝对构型 我们感谢Jeff de Ropp和John MacMillan（加利福尼亚大学戴维斯分校）分别在600和400 MHz 1H NMR光谱方面提供的帮助；感谢Gillian Nicholas（加利福尼亚大学戴维斯分校）测量7 a、b的圆二色光谱；感谢Rich Kondrat（加利福尼亚大学河滨分校质谱分析设施）进行化学电离质谱分析；感谢Carlito Lebrilla和Yongming Xie（加利福尼亚大学戴维斯分校）进行基质辅助激光解吸/电离质谱分析。本研究得到了美国国立卫生研究院（NIH；资助号AI 39987）的支持。核磁共振光谱仪部分由美国国家科学基金会（资助号CHE-9808183；400 MHz仪器）和美国国立卫生研究院（资助号RR11973；600 MHz仪器）资助。CD=圆二色性
Angew Chem Int Ed Engl. 2000 Nov 17;39(22):4076-4079.
9
(2,6-Mes(2)H(3)C(6))(2)BiH, a Stable, Molecular Hydride of a Main Group Element of the Sixth Period, and Its Conversion to the Dibismuthene (2,6-Mes(2)H(3)C(6))BiBi(2,6-Mes(2)C(6)H(3)) This work was supported by the National Science Foundation. The Bruker SMART 1000 difractometer was funded in part by NSF Instrumentation Grant CHE-9808259. Mes=2,4,6-Me(3)C(6)H(2).（2,6-二甲基苯基）₂BiH，一种第六周期主族元素的稳定分子氢化物，及其向二铋烯（2,6-二甲基苯基）BiBi（2,6-二甲基苯基）的转化 本研究得到美国国家科学基金会的支持。布鲁克SMART 1000衍射仪部分由美国国家科学基金会仪器资助项目CHE-9808259资助。Mes=2,4,6-三甲基苯基。
Angew Chem Int Ed Engl. 2000 Aug 4;39(15):2771-2773. doi: 10.1002/1521-3773(20000804)39:15<2771::aid-anie2771>3.0.co;2-7.
10
Total Synthesis of (-)-Spirotryprostatin B and Three Stereoisomers We thank NIH NIGMS (GM-30859) for financial support, Prof. A. J. Shaka and N. D. Taylor for DPFGSE experiments, Prof. H. Osada for providing spectral data for natural 1, and Prof. R. M. Williams and P. R. Sebahar for providing spectral data and a sample of synthetic ent-21. We are also grateful to Prof. R. M. Williams and Prof. S. J. Danishefsky for open exchange of information prior to publication. NMR and mass spectra were determined at UC Irvine with instruments purchased with the assistance of the NSF and NIH shared instrumentation programs.
Angew Chem Int Ed Engl. 2000 Dec 15;39(24):4596-4599.

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