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Asymmetric, Stereocontrolled Total Synthesis of Paraherquamide A This work was supported by the NIH (Grant CA 70375). The Japanese Society for the Promotion of Science (JSPS) is acknowledged for providing support to H.T. Mass spectra were obtained on instruments supported by the NIH Shared Instrumentation Grant (GM 49631). We also wish to thank Dr. Timothy Blizzard (Merck & Co.) for providing an authentic sample of natural paraherquamide A. We also wish to acknowledge Dr. Byung H. Lee (Pharmacia-Upjohn Co.) for providing NMR spectra and an authentic specimen of 14-oxoparaherquamide B. We also wish to thank Dr. Alfredo Vazquez for assistance with purification and characterization of synthetic paraherquamide A.

作者信息

Williams RM, Cao J, Tsujishima H

机构信息

Department of Chemistry Colorado State University Fort Collins, CO 80523 (USA).

出版信息

Angew Chem Int Ed Engl. 2000 Jul 17;39(14):2540-2544. doi: 10.1002/1521-3773(20000717)39:14<2540::aid-anie2540>3.0.co;2-r.

DOI:10.1002/1521-3773(20000717)39:14<2540::aid-anie2540>3.0.co;2-r
PMID:10941129
Abstract
摘要

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1
Asymmetric, Stereocontrolled Total Synthesis of Paraherquamide A This work was supported by the NIH (Grant CA 70375). The Japanese Society for the Promotion of Science (JSPS) is acknowledged for providing support to H.T. Mass spectra were obtained on instruments supported by the NIH Shared Instrumentation Grant (GM 49631). We also wish to thank Dr. Timothy Blizzard (Merck & Co.) for providing an authentic sample of natural paraherquamide A. We also wish to acknowledge Dr. Byung H. Lee (Pharmacia-Upjohn Co.) for providing NMR spectra and an authentic specimen of 14-oxoparaherquamide B. We also wish to thank Dr. Alfredo Vazquez for assistance with purification and characterization of synthetic paraherquamide A.对羟基赫曲霉素A的不对称、立体控制全合成 本研究得到了美国国立卫生研究院(拨款号CA 70375)的支持。感谢日本学术振兴会(JSPS)对H.T.的支持。质谱是在由美国国立卫生研究院共享仪器拨款(GM 49631)支持的仪器上获得的。我们还感谢蒂莫西·布莱兹德博士(默克公司)提供天然对羟基赫曲霉素A的真品样品。我们还要感谢李炳焕博士(法玛西亚-普强公司)提供核磁共振谱以及14-氧代对羟基赫曲霉素B的真品标本。我们还要感谢阿尔弗雷多·巴斯克斯博士在合成对羟基赫曲霉素A的纯化和表征方面提供的帮助。
Angew Chem Int Ed Engl. 2000 Jul 17;39(14):2540-2544. doi: 10.1002/1521-3773(20000717)39:14<2540::aid-anie2540>3.0.co;2-r.
2
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