Kneussel M, Betz H
Dept of Neurochemistry, Max-Planck-Institute for Brain Research, D-60528 Frankfurt/Main, Germany.
Trends Neurosci. 2000 Sep;23(9):429-35. doi: 10.1016/s0166-2236(00)01627-1.
Recent studies indicate an important role of cytoskeleton-associated and lipid-anchored proteins in the formation of inhibitory postsynaptic membrane specializations. Membrane apposition of the tubulin-binding protein gephyrin is essential for the recruitment of inhibitory glycine receptors and GABAA receptors to developing postsynaptic sites. Newly disclosed interactions between gephyrin, exchange factors for G proteins of the Rho and Rac families, the translational regulator RAFT1, and actin-binding proteins like profilin might integrate activity-dependent and trophic-factor-mediated signals at developing postsynaptic sites. A model of inhibitory neurotransmitter receptor clustering, is proposed, in which this process is initiated by receptor-driven activation of phosphatidylinositol 3-kinase.
最近的研究表明，细胞骨架相关蛋白和脂锚定蛋白在抑制性突触后膜特化的形成中起重要作用。微管蛋白结合蛋白gephyrin的膜附着对于将抑制性甘氨酸受体和GABAA受体募集到发育中的突触后位点至关重要。新发现的gephyrin、Rho和Rac家族G蛋白的交换因子、翻译调节因子RAFT1以及诸如丝切蛋白等肌动蛋白结合蛋白之间的相互作用，可能会在发育中的突触后位点整合活性依赖和营养因子介导的信号。本文提出了一种抑制性神经递质受体聚集模型，其中该过程由受体驱动的磷脂酰肌醇3激酶激活引发。
