氟硝西泮的残留效应。
Residual effects of flunitrazepam.
作者信息
Bond A J, Lader M H
出版信息
Br J Clin Pharmacol. 1975 Apr;2(2):143-50. doi: 10.1111/j.1365-2125.1975.tb01569.x.
Abstract
1 Twelve normal subjects were tested on a large battery of tests after a hypnotic dose of flunitrazepam(1 or 2 mg) and a placebo. Psychological tests were given 12 h after the drug and physiological tests 12, 15 and 18 h after the drug. 2 The tests included self-ratings of hypnotic effects and mood, the electroencephalogram, the auditory electroencephalographic evoked response, skin conductance, tapping, card-sorting and the symbol copying test. 3 Both doses of flunitrazepam were effective hypnotics according to the ratings, with an anxiolytic effect the following day. The EEG was significantly altered up to 18 h after the drug and the behavioural tests showed a motor impairment 12 h after drug administration. 4 Nearly all changes displayed linear dose-related trends.
摘要
- 12名正常受试者在服用催眠剂量的氟硝西泮（1毫克或2毫克）和安慰剂后，接受了一系列大量测试。服药12小时后进行心理测试，服药12、15和18小时后进行生理测试。2. 测试包括对催眠效果和情绪的自我评分、脑电图、听觉脑电图诱发反应、皮肤电导、敲击、卡片分类和符号复制测试。3. 根据评分，两种剂量的氟硝西泮都是有效的催眠药，第二天有抗焦虑作用。服药后18小时内脑电图有显著变化，行为测试显示给药12小时后有运动障碍。4. 几乎所有变化都呈现出与剂量相关的线性趋势。
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本文引用的文献
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