二氯醛比林、氟硝西泮和异戊巴比妥钠对正常受试者睡眠及清晨行为某些方面影响的重复剂量比较
A repeated dose comparison of dichloralphenazone, flunitrazepam and amylobarbitone sodium on some aspects of sleep and early morning behaviour in normal subjects.
作者信息
Hindmarch I, Parrott A C, Arenillas L
出版信息
Br J Clin Pharmacol. 1977 Apr;4(2):229-33. doi: 10.1111/j.1365-2125.1977.tb00699.x.
Abstract
1 Seven normal subjects were given three different hypnotics (flunitrazepam 1 mg, amylobarbitone sodium 100 mg and dichloralphenazone 1300 mg) for four consecutive nights each. 2 All three substances improved subjective assessment of the ease of getting to sleep. Flunitrazepam was rated as better than eithr dichloralphenazone or amylobarbitone sodium in this respect. 3 The perceived quality of induced sleep was not altered by any of the preparations. 4 There was a disturbance of the subjective ratings of getting to sleep following cessation of treatment with dichloralphenazone, giving tentative support to the existence of a 'rebound' effect. 5 Dichloralphenazone produced an impairment in psychomotor performance as measured on a complex reaction time test following four nights medication with the drug.
摘要
七名正常受试者连续四晚每晚服用三种不同的催眠药（氟硝西泮1毫克、戊巴比妥钠100毫克和二氯醛苯腙1300毫克）。
所有这三种药物都改善了对入睡难易程度的主观评价。在这方面，氟硝西泮的评分优于二氯醛苯腙或戊巴比妥钠。
诱导睡眠的感知质量没有因任何一种制剂而改变。
停用二氯醛苯腙后，入睡的主观评分出现紊乱，初步支持了“反跳”效应的存在。
在连续四晚服用二氯醛苯腙后进行的复杂反应时间测试中，该药导致精神运动表现受损。
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