Conrad K H, Heinen G
Med Klin. 1975 Mar 28;70(13):558-62.
A report about the treatment of 85 women in the premenopause during 387 cycles is given. The treatment consisted in sequential therapy in form of conjugated Estrogens (Presomen) and a new synthetic Gestagen, which was given in three different modifications: from the fifth to the 24-th day of the cycle 1,25 mg Presomen a day, additionally on the last five, seven or ten days, during each period 6 respectively 5 mg Gestagen a day. It proved that both, the disfunctional haemorrhages as well as the climacteric syndrome, were favourably influenced. The mode 10+10, that is, 10 days Estrogens alone + 10 days combined with ;estagen, proved best. A sufficiently secure contraception is not guaranteed. This can be recognized by the occurence of biphasic basal temperature curves.
本文报告了对85名处于绝经前期的女性进行387个周期治疗的情况。治疗采用序贯疗法，使用结合雌激素（普瑞马林）和一种新型合成孕激素，后者有三种不同的给药方式：在周期的第5天至第24天，每天服用1.25毫克普瑞马林，在每个周期的最后5天、7天或10天，每天额外服用6毫克或5毫克孕激素。结果表明，功能失调性子宫出血和更年期综合征均受到了积极影响。10 + 10模式，即单独服用10天雌激素 + 与雌激素联合服用10天，效果最佳。但无法保证足够可靠的避孕效果。这可通过双相基础体温曲线的出现得以确认。
