Rachev E
Akush Ginekol (Sofiia). 1989;28(2):75-8.
Single-hormone prophylaxis with gestagen (Primolut nor) was carried out on 62 women with uterine bleedings during the premenopause of climacteric at mean age of 46.8 years. A ten-day scheme with application of 5 mg of gestagen daily from 16 to 25 day of the cycle for a period of 6 months was used. The treatment provided stable clinical characteristic of the successive pseudomenstrual cycles could continue for a considerable time practically till disappearance of pseudo-menstruation and transition of the woman in postmenopause. Primolut nor was a convenient drug also in women under continuous anticoagulant treatment. However it was effective and could not be used for treatment of accompanied climacteric symptoms.
对平均年龄为46.8岁的62名处于更年期绝经前期子宫出血的女性进行了单一激素孕激素（炔诺酮）预防治疗。采用了一种为期十天的方案，从周期的第16天至第25天每天应用5毫克孕激素，持续6个月。该治疗使连续假月经周期具有稳定的临床特征，实际上可以持续相当长的时间，直至假月经消失且女性进入绝经后期。炔诺酮对于正在接受持续抗凝治疗的女性也是一种方便的药物。然而，它有效但不能用于治疗伴随的更年期症状。
