Guerrant R L, Lima A A, Davidson F
Division of Geographic and International Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908-1379, USA.
J Infect Dis. 2000 Sep;182 Suppl 1:S134-8. doi: 10.1086/315924.
Symposium presentations have focused on the elegant molecular science and the biologic mechanisms by which micronutrients play critical roles in cellular and humoral immune responses, cellular signaling and function, and even in the evolution of microbial virulence. The concluding session examined the practical issues of how best to evaluate the nutritionally at-risk host, especially in the areas of greatest need-an analytical model of nutrient-immune interactions, implications of nutritional modulation of the immune response for disease, and the implications for international research and child health. This overview illustrated how malnutrition may be a major consequence of early childhood diarrhea and enteric infections, as enteric infections may critically impair intestinal absorptive function with potential long-term consequences for growth and development. The potentially huge, largely undefined DALY (disability-adjusted life years) impact of early childhood diarrheal illnesses demonstrates the importance of quantifying the long-term functional impact of largely preventable nutritional and infectious diseases, especially in children in developing areas.
专题研讨会的报告聚焦于精妙的分子科学以及微量营养素在细胞免疫和体液免疫反应、细胞信号传导与功能，甚至在微生物毒力演变过程中发挥关键作用的生物学机制。闭幕会议探讨了如何以最佳方式评估营养风险较高的宿主这一实际问题，尤其是在最迫切需要的领域——营养与免疫相互作用的分析模型、免疫反应的营养调节对疾病的影响，以及对国际研究和儿童健康的影响。本综述阐述了营养不良如何可能成为幼儿腹泻和肠道感染的主要后果，因为肠道感染可能严重损害肠道吸收功能，对生长发育产生潜在的长期影响。幼儿腹泻疾病对伤残调整生命年（DALY）可能产生的巨大且很大程度上未明确的影响，表明了量化主要可预防的营养和传染病的长期功能影响的重要性，特别是在发展中地区的儿童中。
