[特应性皮炎婴幼儿患者血清中一氧化氮产物、白细胞介素-8、调节激活正常T细胞表达和分泌的趋化因子及嗜酸性粒细胞趋化蛋白的水平]

[Serum levels of NO products, IL-8, RANTES and eotaxin in infantile patients with atopic dermatitis].

作者信息

Kurita F

机构信息

Second Department of Pediatrics, Toho University, Tokyo, Japan.

出版信息

Arerugi. 2000 Jul;49(7):577-84.

PMID:10944824

Abstract

Inflammatory mechanisms play an important role in the pathogenesis and the expansion of the skin lesion in AD. The serum levels of NO product, IL-8, RANTES and eotaxin, which are considered to an index of the inflammatory response, were measured in infants diagnosed as AD. The serum levels of NO product, RANTES and eotaxin were higher in the infantile AD patients with the systemic skin lesion compared with controls. The higher levels of NO product were shown with the expansion of the skin lesion. In AD patients, the serum levels of NO product were significantly correlated with the serum levels of eotaxin (r = 0.615, p < 0.001). These results suggest that NO product bears an important function in the allergic inflammation, which is concerned with the lesion expansion of the infantile AD patients and may be an index of the allergic inflammation.

摘要

炎症机制在特应性皮炎（AD）的发病机制及皮肤损害扩展中起重要作用。对诊断为AD的婴儿测定了血清中一氧化氮（NO）产物、白细胞介素-8（IL-8）、调节激活正常T细胞表达和分泌因子（RANTES）及嗜酸性粒细胞趋化因子的水平，这些被视为炎症反应的指标。与对照组相比，患有全身性皮肤损害的婴儿特应性皮炎患者血清中NO产物、RANTES及嗜酸性粒细胞趋化因子水平更高。随着皮肤损害的扩展，NO产物水平升高。在AD患者中，血清NO产物水平与嗜酸性粒细胞趋化因子水平显著相关（r = 0.615，p < 0.001）。这些结果表明，NO产物在过敏性炎症中起重要作用，这与婴儿特应性皮炎患者的皮损扩展有关，且可能是过敏性炎症的一个指标。