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[主动脉缩窄的一期支架植入术:中期随访]

[Primary stent implantation in aortic coarctation: mid-term follow-up].

作者信息

Alcibar J, Peña N, Oñate A, Cabrera A, Galdeano J M, Pastor E, Inguanzo R, Vitoria Y, Gómez S, Arana J I, Barrenechea J I

机构信息

Sección de Hemodinámica, Hospital de Cruces, Vizcaya.

出版信息

Rev Esp Cardiol. 2000 Jun;53(6):797-804. doi: 10.1016/s0300-8932(00)75160-8.

Abstract

BACKGROUND

The use of balloon-expandable stents provides an effective alternative therapy in patients with stenotic lesions in congenital heart disease. Stents implantation has served to improve the results and to reduce complications of balloon angioplasty for coarctation and recoarctation of the aorta.

OBJECTIVE

We report our results after primary stents implantation for coarctation and recoarctation of the aorta.

PATIENTS AND METHODS

Balloon-expandable stents were implanted in 14 patients (mean age 20 +/- 12 years) with coarctation of the aorta (11 native and 3 postoperative); 2 patients had associated malformations. The morphology varied: 10 resembled a located-diaphragm (one of them with moderate arch hypoplasia); 2 had distorted coarctation and 2 had a complete aortal obstruction. Five patients were hypertensive and 1 had cardiogenic shock and severe arrhythmias which did not respond to intensive medical therapy. In all cases 14 Palmaz stents (7 P308 and 7 P4014) were implanted with the primary technique through a Mullin's sheath. The balloon-to-descending aorta diameter ratio, measured at the level of the diaphragm, was 1. A special technique was carried out in the 2 cases with complete aortal obstruction.

RESULTS

The procedure was effective in all 14 cases. The coarctation diameter increased from 4 +/- 2 to 15 +/- 2 mm (p < 0.0001) and transcoarctation systolic pressure gradient decreased from 43 +/- 19 to 2 +/- 2 mmHg (p < 0.0001). The ratio of the coarctation to descending aorta diameter measured at the level of the diaphragma increased from 0.3 +/- 0.1 to 0.95 +/- 0.05 (p < 0.001). At 19 +/- 8 months follow up, all patients showed sustained clinical improvement. The patient with complete aortal obstruction experienced a dramatic improvement, but she died from a sudden cardiac event 22 months after the procedure. At angiographic follow up in 7 patients, 1 year after implantation, no recoarctation was observed with secondary vessels patent, and absence of restenosis.

CONCLUSIONS

a) Percutaneous endovascular stents implantation in coarctation and recoarctation of the aorta may become an effective treatment modality in the older child, adolescent and adults; b) stents are particularly attractive in those patients with a more complex anatomy and higher surgical risk; c) primary stenting is expected to have a lower rate of complications, and d) we describe a special technique with a right femoral-left humeral arterial circuit that is successfully applied to patients with complete aortal obstruction.

摘要

背景

对于先天性心脏病狭窄性病变患者,使用球囊扩张支架提供了一种有效的替代治疗方法。支架植入已有助于改善主动脉缩窄和再缩窄的球囊血管成形术的效果并减少并发症。

目的

我们报告主动脉缩窄和再缩窄初次支架植入后的结果。

患者和方法

对14例主动脉缩窄患者(平均年龄20±12岁)(11例为原发,3例为术后)植入球囊扩张支架;2例伴有相关畸形。形态各异:10例类似局限性隔膜(其中1例有中度主动脉弓发育不全);2例为扭曲型缩窄,2例为完全性主动脉梗阻。5例患者有高血压,1例有心源性休克和严重心律失常,强化药物治疗无效。所有病例均通过Mullin鞘管采用初次技术植入14枚Palmaz支架(7枚P308和7枚P4014)。在隔膜水平测量的球囊与降主动脉直径比为1。对2例完全性主动脉梗阻患者采用了特殊技术。

结果

该手术在所有14例患者中均有效。缩窄处直径从4±2mm增加至15±2mm(p<0.0001),缩窄段收缩期压力阶差从43±19mmHg降至2±2mmHg(p<0.0001)。在隔膜水平测量的缩窄处与降主动脉直径比从0.3±0.1增加至0.95±0.05(p<0.001)。在19±8个月的随访中,所有患者临床持续改善。完全性主动脉梗阻的患者有显著改善,但在手术后22个月死于心脏突发事件。在7例患者植入后1年的血管造影随访中,未观察到再缩窄,二级血管通畅,无再狭窄。

结论

a)经皮血管内支架植入治疗主动脉缩窄和再缩窄可能成为大龄儿童、青少年和成人的一种有效治疗方式;b)支架对于解剖结构更复杂、手术风险更高的患者尤其有吸引力;c)初次支架植入预计并发症发生率更低;d)我们描述了一种采用右股动脉-左肱动脉回路的特殊技术,该技术已成功应用于完全性主动脉梗阻患者。

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