Sawh R N, Lele S M, Borkowski J, Ventura K C, Zaharopoulos P, Logroño R
Division of Cytopathology, Department of Pathology, University of Texas Medical Branch, Galveston 77555-0548, USA.
Diagn Cytopathol. 2000 Sep;23(3):187-91. doi: 10.1002/1097-0339(200009)23:3<187::aid-dc9>3.0.co;2-y.
The fine-needle aspiration biopsy (FNAB) findings in two cases of hemangiopericytoma (HP), arising in the parotid gland and on the inner chest wall, respectively, are reported. Smear preparations in each case showed cytologic features of an undifferentiated spindle-cell neoplasm, whereas a core needle biopsy specimen of the chest wall mass showed a spindle-cell tumor with a "staghorn-like" arrangement of endothelium-lined vascular channels. Immunostains performed on this core biopsy, and on the surgical resection specimens in both cases, showed positive staining of tumor cells for vimentin and CD34, with negative staining for a variety of smooth muscle, epithelial, neural, and neuroendocrine markers. Electron microscopy performed in one case further supported the diagnosis of HP. With adequate sampling and appropriate use of ancillary studies, a diagnosis of HP can be reliably suggested on the basis of FNAB and core biopsy of a soft-tissue mass.
报告了分别发生于腮腺和胸壁内侧的两例血管外皮细胞瘤（HP）的细针穿刺活检（FNAB）结果。每例涂片标本均显示未分化梭形细胞肿瘤的细胞学特征，而胸壁肿块的粗针活检标本显示为梭形细胞瘤，其内皮细胞衬里的血管通道呈“鹿角样”排列。对该粗针活检标本以及两例手术切除标本进行的免疫染色显示，肿瘤细胞波形蛋白和CD34染色呈阳性，而多种平滑肌、上皮、神经和神经内分泌标志物染色呈阴性。对其中一例进行的电子显微镜检查进一步支持了HP的诊断。通过充分取材并适当使用辅助检查，基于软组织肿块的FNAB和粗针活检能够可靠地提示HP的诊断。
