Boggino H E, Fernandez M P, Logroño R
Department of Pathology, University of Texas Medical Branch at Galveston, 77555-0548, USA.
Diagn Cytopathol. 2000 Sep;23(3):156-60. doi: 10.1002/1097-0339(200009)23:3<156::aid-dc3>3.0.co;2-p.
Gastrointestinal stromal tumors (GISTs) comprise a heterogeneous group of neoplasms of the gastrointestinal tract previously referred to as leiomyomas, leiomyosarcomas, or schwannomas. GISTs derive from the interstitial cell of Cajal and, in addition to variable expression of smooth muscle and neural markers, they characteristically express CD34 and CD117. To our knowledge, the cytologic appearance of gastric neoplasms designated as GISTs has never been reported. We illustrate the fine-needle aspiration (FNA) cytology findings of a gastric stromal tumor having spindle cells with delicate cytoplasm and prominent nuclear palisading. Consistent core biopsy and immunochemistry findings further supported the diagnosis of GIST. Pathologic evaluation of the resected tumor confirmed the cytologic diagnosis. In the appropriate clinical and radiologic setting, a confident diagnosis of GIST can be established by FNA cytology and core biopsy. The roles of immunochemical stains and other ancillary techniques in reaching the correct diagnosis are addressed.
胃肠道间质瘤（GISTs）是一组异质性的胃肠道肿瘤，以前被称为平滑肌瘤、平滑肌肉瘤或神经鞘瘤。GISTs起源于 Cajal 间质细胞，除了平滑肌和神经标志物的可变表达外，它们还特征性地表达 CD34 和 CD117。据我们所知，尚未有关于被指定为 GISTs 的胃肿瘤细胞学表现的报道。我们展示了一例胃间质瘤的细针穿刺（FNA）细胞学检查结果，该肿瘤具有梭形细胞，胞质细腻，核呈栅栏状排列。一致的芯针活检和免疫化学结果进一步支持了 GIST 的诊断。切除肿瘤的病理评估证实了细胞学诊断。在适当的临床和放射学背景下，通过 FNA 细胞学检查和芯针活检可以确诊 GIST。本文探讨了免疫化学染色和其他辅助技术在做出正确诊断中的作用。
