Matheson P J, Wilson M A, Garrison R N
Center for Excellence in Applied Microcirculatory Research, University of Louisville, Louisville, Kentucky 40292, USA.
J Surg Res. 2000 Sep;93(1):182-96. doi: 10.1006/jsre.2000.5862.
The gastrointestinal system anatomically is positioned to perform two distinct functions: to digest and absorb ingested nutrients and to sustain barrier function to prevent transepithelial migration of bacteria and antigens. Alterations in these basic functions contribute to a variety of clinical scenarios. These primary functions intrinsically require splanchnic blood flow at both the macrovascular and microvascular levels of perfusion. Therefore, a greater understanding of the mechanisms that regulate intestinal vascular perfusion in the normal state and during pathophysiological conditions would be beneficial. The purpose of this review is to summarize the current understanding regarding the regulatory mechanisms of intestinal blood flow in fasted and fed conditions and during pathological stress.
消化和吸收摄入的营养物质，以及维持屏障功能以防止细菌和抗原经上皮迁移。这些基本功能的改变会导致多种临床情况。这些主要功能本质上需要在大血管和微血管灌注水平上的内脏血流量。因此，更深入了解在正常状态和病理生理条件下调节肠道血管灌注的机制将是有益的。本综述的目的是总结目前对禁食和进食条件下以及病理应激期间肠道血流调节机制的认识。
