Von Beck A, Friedrich F
Wien Klin Wochenschr. 1975 Jan 24;87(2):59-62.
0.25 sodium equilin sulphate and 0.625 mg Premarin were compared as to their effects in 12 postmenopausal syndrome. The initial daily dosage of 0.25 mg equilin had a stronger oestrongenic effect in the alleviation of vasomotor disturbances than subsequently-administered Premarin. No significant difference was found in effect on the vaginal epithelium or the endometrium or in the incidence of irregular bleeding. The number of women in whom withdrawal bleeding was reported was considerably reduced by lowering the dosage to 0.2 mg equilin sulphate. Consequently 0.2 to 0.3 mg equilin sulphate must be considered the optimum dosage.
比较了0.25毫克硫酸马萘雌酮和0.625毫克倍美力对12例绝经后综合征的疗效。初始每日剂量0.25毫克马萘雌酮在缓解血管舒缩障碍方面的雌激素作用比随后给予的倍美力更强。在对阴道上皮、子宫内膜的作用或不规则出血的发生率方面未发现显著差异。将硫酸马萘雌酮剂量降至0.2毫克时，报告有撤退性出血的女性人数大幅减少。因此，0.2至0.3毫克硫酸马萘雌酮必须被视为最佳剂量。
