Pollack J G, Hickey T L
J Comp Neurol. 1979 Jun 15;185(4):587-602. doi: 10.1002/cne.901850402.
The retino-collicular projections in rhesus monkeys were studied using standard autoradiographic and degeneration techniques. A computer based technique was developed which provided a flattened visual display of the retinal projection onto the entire superior colliculus, quantified the area covered by such projections for different segments of the colliculus and showed how this morphological pattern varied with depth beneath the collicular surface. In the anterolateral third of the colliculus (i.e., the foveal representation) the retinal projection was light, confined to a narrow region of the superficial gray and contributed primarily by the contralateral eye. In the remaining binocular segment of the superior colliculus the retinal projections showed a marked degree of local patterning, that in many instances appeared as bands of label. By combining eye removal and eye injection procedures in a single animal and comparing adjacent sections processed for autoradiography and stained for degeneration, it was possible to assess the amount of overlap between retino-collicular projections from the two eyes. These experiments showed that total segregation of retinal afferents does occur in the monkey superior colliculus, but what occurs more often is a situation where the density of inputs from the two eyes varies reciprocally as one moves across the part of the colliculus that represents the binocular visual field.
利用标准放射自显影和变性技术研究了恒河猴的视网膜-丘脑投射。开发了一种基于计算机的技术，该技术提供了视网膜投射到整个上丘的平面视觉显示，量化了上丘不同节段这种投射所覆盖的面积，并显示了这种形态模式如何随上丘表面以下深度而变化。在上丘的前外侧三分之一处（即中央凹代表区），视网膜投射较淡，局限于浅灰质的一个狭窄区域，主要由对侧眼贡献。在上丘其余的双眼节段，视网膜投射显示出明显程度的局部模式，在许多情况下表现为标记带。通过在同一只动物中结合眼球摘除和眼球注射程序，并比较用于放射自显影处理和变性染色的相邻切片，可以评估来自两眼的视网膜-丘脑投射之间的重叠量。这些实验表明，视网膜传入纤维的完全分离确实发生在猴的上丘，但更常见的情况是，当从代表双眼视野的上丘部分移动时，来自两眼的输入密度呈反向变化。
