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本文引用的文献

1
The role of T cells in Trypanosoma cruzi infections.T细胞在克氏锥虫感染中的作用。
Parasitol Today. 1995 Jan;11(1):7-9. doi: 10.1016/0169-4758(95)80095-6.
2
Cell-mediated immunity in experimental Trypanosoma cruzi infection.实验性克氏锥虫感染中的细胞介导免疫
Parasitol Today. 1997 Sep;13(9):335-42. doi: 10.1016/s0169-4758(97)01073-9.
3
Therapeutic activity and criterion of cure on mice experimentally infected with Trypanosoma cruzi.对实验感染克氏锥虫的小鼠的治疗活性和治愈标准
Rev Inst Med Trop Sao Paulo. 1962 Nov-Dec;4:389-96.
4
Chagas disease etiology: autoimmunity or parasite persistence?恰加斯病的病因：自身免疫还是寄生虫持续存在？
Parasitol Today. 1999 Mar;15(3):94-9. doi: 10.1016/s0169-4758(99)01398-8.
5
Vaccination with trypomastigote surface antigen 1-encoding plasmid DNA confers protection against lethal Trypanosoma cruzi infection.用编码锥鞭毛体表面抗原1的质粒DNA进行疫苗接种可提供针对致命性克氏锥虫感染的保护作用。
Infect Immun. 1998 Nov;66(11):5073-81. doi: 10.1128/IAI.66.11.5073-5081.1998.
6
The relative contribution of antibody production and CD8+ T cell function to immune control of Trypanosoma cruzi.抗体产生和CD8 + T细胞功能对克氏锥虫免疫控制的相对贡献。
Parasite Immunol. 1998 May;20(5):207-16. doi: 10.1046/j.1365-3024.1998.00154.x.
7
Immunization with a plasmid DNA containing the gene of trans-sialidase reduces Trypanosoma cruzi infection in mice.用含有转唾液酸酶基因的质粒DNA进行免疫可降低小鼠感染克氏锥虫的几率。
Vaccine. 1998 May;16(8):768-74. doi: 10.1016/s0264-410x(97)00277-6.
8
Stable transfection of Trypanosoma cruzi epimastigotes with the trypomastigote-specific complement regulatory protein cDNA confers complement resistance.用锥鞭毛体特异性补体调节蛋白cDNA对克氏锥虫上鞭毛体进行稳定转染可赋予补体抗性。
Infect Immun. 1998 Jun;66(6):2460-5. doi: 10.1128/IAI.66.6.2460-2465.1998.
9
DNA vaccines.DNA疫苗
Annu Rev Immunol. 1997;15:617-48. doi: 10.1146/annurev.immunol.15.1.617.
10
"Autoimmune rejection" of neonatal heart transplants in experimental Chagas disease is a parasite-specific response to infected host tissue.实验性恰加斯病中新生儿心脏移植的“自身免疫排斥”是对受感染宿主组织的寄生虫特异性反应。
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3932-7. doi: 10.1073/pnas.94.8.3932.

基于克氏锥虫补体调节蛋白的DNA免疫引发补体溶解抗体并赋予抗克氏锥虫感染的保护作用。

DNA-Based immunization with Trypanosoma cruzi complement regulatory protein elicits complement lytic antibodies and confers protection against Trypanosoma cruzi infection.

作者信息

Sepulveda P, Hontebeyrie M, Liegeard P, Mascilli A, Norris K A

机构信息

Department of Immunology, Pasteur Institute, Paris 15, France.

出版信息

Infect Immun. 2000 Sep;68(9):4986-91. doi: 10.1128/IAI.68.9.4986-4991.2000.

DOI:10.1128/IAI.68.9.4986-4991.2000
PMID:10948115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC101717/
Abstract

A complement regulatory protein (CRP) of Trypanosoma cruzi was evaluated as a vaccine candidate in a murine model of experimental T. cruzi infection. Recombinant CRP derived from an Escherichia coli expression system and a plasmid encoding the full-length crp structural gene under the control of a eukaryotic promoter were used to immunize BALB/c mice. Immunization with both protein and DNA vaccines resulted in a Th1-type T-cell response, comparable antibody titers, and similar immunoglobulin G isotype profiles. Only mice immunized with the crp DNA plasmid produced antibodies capable of lysing the parasites in the presence of complement and were protected against a lethal challenge with T. cruzi trypomastigotes. These results demonstrate the superiority of DNA immunization over protein immunization with the recombinant CRP. The work also supports the further investigation of CRP as a component of a multigene, anti-T. cruzi DNA vaccine.

摘要

在克氏锥虫实验性感染的小鼠模型中，对克氏锥虫的一种补体调节蛋白（CRP）作为候选疫苗进行了评估。源自大肠杆菌表达系统的重组CRP以及在真核启动子控制下编码全长crp结构基因的质粒被用于免疫BALB/c小鼠。蛋白质疫苗和DNA疫苗免疫均导致Th1型T细胞反应、相当的抗体滴度和相似的免疫球蛋白G同种型谱。只有用crp DNA质粒免疫的小鼠产生了在补体存在下能够裂解寄生虫的抗体，并受到了克氏锥虫锥鞭毛体致死攻击的保护。这些结果证明了DNA免疫相对于重组CRP蛋白质免疫的优越性。这项工作还支持进一步研究将CRP作为多基因抗克氏锥虫DNA疫苗的一个组成部分。