[帕金森病的实验模型]
[Experimental models, of Parkinson disease].
作者信息
Luquin M R
机构信息
Departamento de Neurología, Clínica Universitaria de Navarra, Pamplona, España.
出版信息
Rev Neurol. 2000;31(1):60-6.
This article reviews the most useful animal models of Parkinson's disease available. Basically they include the model of unilateral nigrostriatal lesion induced by 6-hydroxydopamine (6-OHDA) in rodents and the 1-methy-4-phenyl-1,2,3,6, tetrahydropyridine (MPTP) model of parkinsonism in non-human primates. The major neurochemical and histological alterations found in these two models are also analyzed. Finally, possible applications of these models of parkinsonism are also discussed.
本文综述了现有的最有用的帕金森病动物模型。基本上，它们包括啮齿动物中由6-羟基多巴胺（6-OHDA）诱导的单侧黑质纹状体损伤模型以及非人类灵长类动物中的帕金森病1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）模型。还分析了在这两种模型中发现的主要神经化学和组织学改变。最后，还讨论了这些帕金森病模型的可能应用。
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