Sasatomi T, Tsuji Y, Tanaka T, Horiuchi H, Hyodo S, Takeuchi K, Nakashima O, Shirouzu K
Department of Surgery, Fukuoka Prefectural Asakura Hospital, Amagi, Japan.
Kurume Med J. 2000;47(2):165-8. doi: 10.2739/kurumemedj.47.165.
Schwann cell tumor occurring in the intestines is rare. A 68-year-old female came to our hospital because of hematemesis. Barium enema and colonoscopic examination revealed submucosal tumor in the sigmoid colon. Laboratory data showed mild anemia. No other abnormal finding was found in the blood chemistry. Tumor marker levels of carcinoembryonic antigen (CEA), CA19-9, alpha feto protein (AFP) and neuron specific enolase (NSE) were within normal limits. The exploratory laparotomy confirmed a large sigmoid colon tumor. She received sigmoid colectomy. The resected specimen was a submucosal tumor with central depression, measuring 4.7 x 3.5 x 3.0 cm in size. The cut surface of the tumor was yellowish hue with necrosis. Histological examination showed spindle-shaped tumor cells with palisading comma-shaped nuclei and the nuclear pleomorphism. Immunohistochemical examination revealed that the tumor was positive for S-100 protein staining, and negative for Actin and for H.H.F. staining. These findings showed that this tumor was of Schwann cell origin. We report here the case in detail of a schwannoma in the sigmoid colon.
发生于肠道的施万细胞瘤很罕见。一名68岁女性因呕血前来我院就诊。钡剂灌肠和结肠镜检查显示乙状结肠有黏膜下肿瘤。实验室检查显示轻度贫血。血液生化检查未发现其他异常。癌胚抗原（CEA）、CA19-9、甲胎蛋白（AFP）和神经元特异性烯醇化酶（NSE）的肿瘤标志物水平均在正常范围内。剖腹探查证实乙状结肠有一个大肿瘤。她接受了乙状结肠切除术。切除的标本是一个有中央凹陷的黏膜下肿瘤，大小为4.7×3.5×3.0厘米。肿瘤切面呈黄色并伴有坏死。组织学检查显示梭形肿瘤细胞，细胞核呈栅栏状排列，呈逗号形，有核多形性。免疫组织化学检查显示肿瘤S-100蛋白染色阳性，肌动蛋白和H.H.F.染色阴性。这些结果表明该肿瘤起源于施万细胞。我们在此详细报告一例乙状结肠施万瘤病例。
