Piepenburg O, Vorbrüggen G, Jäckle H
Max-Planck-Institut für biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Göttingen, Germany.
Mol Cell. 2000 Jul;6(1):203-9.
Body structures of Drosophila develop through transient developmental units, termed parasegments, with boundaries lying between the adjacent expression domains of wingless and engrailed. Parasegments are transformed into the morphologically distinct segments that remain fixed. Segment borders are established adjacent and posterior to each engrailed domain. They are marked by single rows of stripe expressing cells that develop into epidermal muscle attachment sites. We show that the positioning of these cells is achieved through repression of Hedgehog signal transduction by Wingless signaling at the parasegment boundary. The nuclear mediators of the two signaling pathways, Cubitus interruptus and Pangolin, function as activator and symmetry-breaking repressor of stripe expression, respectively.
果蝇的身体结构通过称为副节的短暂发育单元发育而成，其边界位于无翅基因和 engrailed 基因相邻的表达域之间。副节会转变为形态上不同且固定不变的节段。节段边界在每个 engrailed 基因表达域的相邻及后方形成。它们由单排表达条纹蛋白的细胞标记，这些细胞会发育成表皮肌肉附着位点。我们发现，这些细胞的定位是通过无翅信号在副节边界处对 Hedgehog 信号转导的抑制来实现的。两条信号通路的核介质，即间断翅脉基因和穿山甲基因，分别作为条纹蛋白表达的激活剂和打破对称性的抑制剂发挥作用。
