Kumle B, Breug R, Boldt J, Münker G
Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum der Stadt Ludwigshafen, Akademisches Lehrkrankenhaus Johannes-Gutenberg-Universität Mainz.
Anasthesiol Intensivmed Notfallmed Schmerzther. 2000 Jul;35(7):423-7. doi: 10.1055/s-2000-5945.
Improvements in the management of patients with cystic fibrosis (CF) result in increased life expectancy. Thus it is likely that anesthetists will see this patients with increasing frequency. This study describes our experiences in the anesthetic management of CF patients.
We descriptively and retrospectively reviewed the records of all CF patients from 1981 until 1997 who underwent elective surgery in our department of ear, nose and throat and in whom general anesthesia was required.
199 anesthetics in 53 patients were reviewed. Premedication with midazolam (0.4 +/- 0.07 mg/kg) were given orally in 163 of the 199 anesthetics (82%). In 45 anesthetics the induction was performed by Inhalation with halothane (23%). Atropine (0.21 +/- 0.11 mg/kg) was used in 69 cases for induction. 57 pulmonary function tests were performed preoperatively mostly showing no severe abnormalities. We documented 10 perioperative respiratory complications (5%) in 199 procedures. No patient died at hospital.
In patients with cystic fibrosis undergoing minor ear, nose and throat surgery who do not show significant reduction in pulmonary function anesthesia can be safely carried out.
囊性纤维化（CF）患者管理的改善使预期寿命延长。因此，麻醉医生可能会越来越频繁地接触到这类患者。本研究描述了我们对CF患者进行麻醉管理的经验。
我们对1981年至1997年间在我院耳鼻喉科接受择期手术且需要全身麻醉的所有CF患者的记录进行了描述性和回顾性审查。
共审查了53例患者的199次麻醉情况。199次麻醉中有163次（82%）口服咪达唑仑（0.4±0.07mg/kg）进行术前用药。45次麻醉通过吸入氟烷进行诱导（23%）。69例诱导时使用了阿托品（0.21±0.11mg/kg）。术前进行了57次肺功能测试，大多数结果显示无严重异常。我们记录了199例手术中有10例围手术期呼吸并发症（5%）。无患者在医院死亡。
对于接受小型耳鼻喉手术且肺功能无显著下降的囊性纤维化患者，可以安全地实施麻醉。
