Felder J B, Korelitz B I, Rajapakse R, Schwarz S, Horatagis A P, Gleim G
Department of Medicine, Lenox Hill Hospital and the New York University School of Medicine, New York 10021, USA.
Am J Gastroenterol. 2000 Aug;95(8):1949-54. doi: 10.1111/j.1572-0241.2000.02262.x.
The aim of this study was to determine whether a relationship exists between the use of nonsteroidal antiinflammatory drugs (NSAIDs) and exacerbation or onset of inflammatory bowel disease (IBD).
Sixty consecutive IBD patients admitted to the hospital were carefully interviewed to ascertain whether they used NSAIDs and the relationship in time and duration to the exacerbation (or onset) of the IBD; 62 patients with irritable bowel syndrome were similarly interviewed and served as controls.
In 31% of our IBD population there was a correlation between use of NSAIDs and IBD activity, whereas in only 2% of the irritable bowel syndrome population who used NSAIDs did this relationship exist.
NSAIDs provoke disease activity in both ulcerative colitis and Crohn's disease and should be avoided in patients with a history of IBD whenever possible.
本研究旨在确定非甾体抗炎药（NSAIDs）的使用与炎症性肠病（IBD）的加重或发作之间是否存在关联。
对连续收治入院的60例IBD患者进行仔细访谈，以确定他们是否使用NSAIDs以及使用时间和持续时间与IBD加重（或发作）的关系；对62例肠易激综合征患者进行类似访谈并作为对照。
在我们的IBD患者群体中，31%的患者NSAIDs使用与IBD活动之间存在相关性，而在使用NSAIDs的肠易激综合征患者群体中，仅有2%存在这种关系。
NSAIDs会引发溃疡性结肠炎和克罗恩病的疾病活动，有IBD病史的患者应尽可能避免使用。
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