Côco Larissa Zambom, de Souza Belisário Eduarda, Vasquez Elisardo Corral, Pereira Thiago Melo Costa, Aires Rafaela, Campagnaro Bianca Prandi
Laboratory of Translational Physiology and Pharmacology, Pharmaceutical Sciences Graduate Program, Vila Velha University (UVV), R Mercurio s/n, 29102623, Vila Velha, 29102-920, ES, Brazil.
Pharmacol Rep. 2025 Jun;77(3):645-657. doi: 10.1007/s43440-025-00724-7. Epub 2025 Apr 11.
Ulcerative colitis is an idiopathic and chronic inflammatory bowel disease, characterized by inflammation of the mucosa of the colon and rectum. Clinical manifestations commonly include abdominal pain, diarrhea (with or without hematochezia), and weight loss. The pathogenesis of ulcerative colitis is multifactorial, involving a combination of genetic predispositions and lifestyle factors. High consumption of processed food, sedentary habits, alcohol intake, and stress are among the lifestyle factors implicated in disease onset and progression. Current treatment strategies focus on managing symptoms and inducing remission, however, the chronic nature of the disease, along with the adverse effects of conventional therapies, often compromises patient's quality of life. Therefore, exploring alternative therapies that can prolong remission and reduce symptom burden is important. Experimental evidence suggests that probiotics may extend remission duration in ulcerative colitis. Moreover, probiotics exhibit efficacy in amelioration clinical symptoms by reducing inflammation markers, preserving, and restoring intestinal epithelial. This review explores the advantages of the administration of probiotics in the treatment of ulcerative colitis, elucidating their mechanism of action.
溃疡性结肠炎是一种特发性慢性炎症性肠病，其特征为结肠和直肠黏膜发炎。临床表现通常包括腹痛、腹泻（伴或不伴便血）以及体重减轻。溃疡性结肠炎的发病机制是多因素的，涉及遗传易感性和生活方式因素的综合作用。加工食品的高摄入量、久坐不动的习惯、酒精摄入和压力等生活方式因素与疾病的发生和进展有关。目前的治疗策略侧重于控制症状和诱导缓解，然而，该疾病的慢性性质以及传统疗法的不良反应常常损害患者的生活质量。因此，探索能够延长缓解期并减轻症状负担的替代疗法很重要。实验证据表明，益生菌可能会延长溃疡性结肠炎的缓解期。此外，益生菌通过降低炎症标志物、保护和恢复肠道上皮来改善临床症状。本综述探讨了益生菌在治疗溃疡性结肠炎中的优势，并阐明其作用机制。
