甘露醇减轻两性霉素B的肾毒性作用。
Mitigation of amphotericin B nephrotoxicity by mannitol.
作者信息
Olivero J J, Lozano-Mendez J, Ghafary E M, Eknoyan G, Suki W N
出版信息
Br Med J. 1975 Mar 8;1(5957):550-1. doi: 10.1136/bmj.1.5957.550.
Abstract
Renal transplant recipients are susceptible to a number of fungal infections amenable to therapy with amphotericin B, but azotaemia is an almost invariable sequel to the use of this agent. As intravenous mannitol has been shown to minimize nephrotoxicity induced by amphotericin B in dogs we treated four kidney transplant recipients who had systemic fungal infections with mannitol and amphotericin B. None showed significant reduction in renal function though a mild metabolic acidosis did develop.
摘要
肾移植受者易患多种可用两性霉素B治疗的真菌感染，但氮质血症几乎是使用该药物后不可避免的后果。由于静脉注射甘露醇已被证明可将两性霉素B对犬类的肾毒性降至最低，我们对4名患有全身性真菌感染的肾移植受者使用甘露醇和两性霉素B进行了治疗。尽管确实出现了轻度代谢性酸中毒，但肾功能均未显著降低。
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