Vitetta E S, Cook R G
J Immunol. 1979 May;122(5):2122-30.
Splenocytes from recombinant mice were radiolabeled before or after deletion of subpopulations by cytotoxic anterisera (+C) directed against I-A, I-E/C, IgM, or Ig. Examination of the lysates of the surviving cells by immunoprecipitation demonstrated that 1) virtually all I-A and I-E/C molecules are co-expressed and synthesized by Ig+, IgM+ lymphocytes, 2) I-A, I-E/C, and IgM molecules are present on many of the cells secreting IgM and IgG, and 3) populations of Ig-bearing or Ig-secreting cells that lack detectable I-A and I-E/C antigens can be identified in spleen cell populations. The co-expression of I-A and I-E/C on most cells of the B cell lineage is discussed in terms of our present concepts of Ir gene control of immune responses.
通过针对I-A、I-E/C、IgM或Ig的细胞毒性抗血清（+C）删除亚群之前或之后，对重组小鼠的脾细胞进行放射性标记。通过免疫沉淀检查存活细胞的裂解物表明：1）几乎所有I-A和I-E/C分子都是由Ig+、IgM+淋巴细胞共表达和合成的；2）I-A、I-E/C和IgM分子存在于许多分泌IgM和IgG的细胞上；3）在脾细胞群体中可以鉴定出缺乏可检测到的I-A和I-E/C抗原的携带Ig或分泌Ig的细胞群体。根据我们目前关于免疫反应的Ir基因控制的概念，讨论了I-A和I-E/C在B细胞系大多数细胞上的共表达。
