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淋巴细胞受体。I. 携带免疫球蛋白、具有抗原结合能力及抗体分泌能力的细胞上的IgG Fc及补体(C3b)受体

Lymphocyte receptors. I. Receptors for Fc of IgG and complement (C3b) on immunoglobulin-bearing, antigen-binding and antibody-secreting cells.

作者信息

McConnell I, Hurd C M

出版信息

Immunology. 1976 Jun;30(6):825-33.

Abstract

Immunoglobulin (Ig) bearing, antigen-binding and antibody-secreting cells were investigated for the presence of membrane receptors for the Fc part of IgG and for C3b on their surface. Fc and C3b receptors were detected on the surface of most Ig-bearing and of most antigen-binding cells. Fc receptors were also detected on IgM antibody-secreting cells but not on IgG-secreting cells. C3b receptors were not detected on any antibody-secreting cells. These receptors are either lost from the B cell surface as they differentiate into antibody-secreting cells or are blocked in vivo by immune complexes or C3b.

摘要

对携带免疫球蛋白(Ig)、具有抗原结合能力和抗体分泌功能的细胞进行研究,以检测其表面是否存在针对IgG的Fc部分和C3b的膜受体。在大多数携带Ig的细胞和大多数抗原结合细胞表面检测到了Fc和C3b受体。在分泌IgM抗体的细胞表面也检测到了Fc受体,但在分泌IgG的细胞表面未检测到。在任何抗体分泌细胞表面均未检测到C3b受体。这些受体要么在B细胞分化为抗体分泌细胞时从其表面丢失,要么在体内被免疫复合物或C3b阻断。

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