• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Serotonin inhibition of the NMDA receptor/nitric oxide/cyclic GMP pathway in human neocortex slices: involvement of 5-HT(2C) and 5-HT(1A) receptors.5-羟色胺对人新皮质切片中N-甲基-D-天冬氨酸受体/一氧化氮/环磷酸鸟苷途径的抑制作用：5-HT(2C)和5-HT(1A)受体的参与
Br J Pharmacol. 2000 Aug;130(8):1853-8. doi: 10.1038/sj.bjp.0703510.
2
Serotonin 5-HT1D and 5-HT1A receptors respectively mediate inhibition of glutamate release and inhibition of cyclic GMP production in rat cerebellum in vitro.血清素5-HT1D和5-HT1A受体分别在体外介导大鼠小脑中谷氨酸释放的抑制和环磷酸鸟苷生成的抑制。
J Neurochem. 1996 Jan;66(1):203-9. doi: 10.1046/j.1471-4159.1996.66010203.x.
3
SB-272183, a selective 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptor antagonist in native tissue.SB - 272183，一种在天然组织中具有选择性的5 - 羟色胺（5 - HT）1A、1B和1D受体拮抗剂。
Br J Pharmacol. 2001 Jul;133(6):797-806. doi: 10.1038/sj.bjp.0704133.
4
5-HT7 receptor-mediated relaxation of the oviduct in nonpregnant proestrus pigs.5-羟色胺7受体介导的未孕发情前期母猪输卵管舒张作用
Eur J Pharmacol. 2003 Feb 14;461(2-3):207-18. doi: 10.1016/s0014-2999(03)01312-8.
5
In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.可溶性鸟苷酸环化酶特异性抑制剂对谷氨酸受体/一氧化氮/环磷酸鸟苷途径的体内微透析研究
Br J Pharmacol. 1996 Oct;119(3):590-4. doi: 10.1111/j.1476-5381.1996.tb15713.x.
6
Activation of serotonergic 5-HT1A receptor reduces Ca(2+)- and glutamatergic receptor-evoked arachidonic acid and No/cGMP release in adult hippocampus.血清素能5-HT1A受体的激活可减少成年海马体中钙离子和谷氨酸能受体诱发的花生四烯酸及一氧化氮/环磷酸鸟苷的释放。
Neurochem Int. 1996 Apr;28(4):439-44. doi: 10.1016/0197-0186(95)00103-4.
7
Trazodone is a potent agonist at 5-HT2C receptors mediating inhibition of the N-methyl-D-aspartate/nitric oxide/cyclic GMP pathway in rat cerebellum.
J Pharmacol Exp Ther. 1998 Jun;285(3):983-6.
8
(1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists.（1-（2,5-二甲氧基-4-碘苯基）-2-氨基丙烷）诱导的大鼠头部抽搐由5-羟色胺（5-HT）2A受体介导：新型5-HT2A/2C拮抗剂、D1拮抗剂和5-HT1A激动剂的调节作用
J Pharmacol Exp Ther. 1995 Apr;273(1):101-12.
9
Activation of presynaptic 5-hydroxytryptamine1-like receptors on glutamatergic terminals inhibits N-methyl-D-aspartate-induced cyclic GMP production in rat cerebellar slices.谷氨酸能终末上的突触前5-羟色胺1样受体的激活抑制大鼠小脑切片中N-甲基-D-天冬氨酸诱导的环磷酸鸟苷生成。
J Pharmacol Exp Ther. 1991 Jun;257(3):1184-8.
10
Effects of various serotonin agonists, antagonists, and uptake inhibitors on the discriminative stimulus effects of methamphetamine in rats.多种血清素激动剂、拮抗剂及摄取抑制剂对大鼠甲基苯丙胺辨别刺激效应的影响。
J Pharmacol Exp Ther. 1999 Oct;291(1):239-50.

引用本文的文献

1
Psilocin, the Psychoactive Metabolite of Psilocybin, Modulates Select Neuroimmune Functions of Microglial Cells in a 5-HT Receptor-Dependent Manner.裸盖菇素，裸盖菇素的精神活性代谢物，以 5-羟色胺受体依赖的方式调节小胶质细胞的选择性神经免疫功能。
Molecules. 2024 Oct 28;29(21):5084. doi: 10.3390/molecules29215084.
2
Withdrawal from chronic alcohol impairs the serotonin-mediated modulation of GABAergic transmission in the infralimbic cortex in male rats.慢性酒精戒断会损害雄性大鼠额下回皮质中 5-羟色胺介导的 GABA 能传递调制。
Neurobiol Dis. 2024 Sep;199:106590. doi: 10.1016/j.nbd.2024.106590. Epub 2024 Jul 10.
3
Metabolomic Signatures of Brainstem in Mice following Acute and Subchronic Hydrogen Sulfide Exposure.急性和亚慢性硫化氢暴露后小鼠脑干的代谢组学特征
Metabolites. 2024 Jan 14;14(1):53. doi: 10.3390/metabo14010053.
4
Neuronal Coordinates Autophagy Induction and Physiological Adaptations to Balance mTORC1 Signalling.神经元协调自噬诱导和生理适应以平衡 mTORC1 信号。
Cells. 2023 Aug 8;12(16):2024. doi: 10.3390/cells12162024.
5
Role of Descending Serotonergic Fibers in the Development of Pathophysiology after Spinal Cord Injury (SCI): Contribution to Chronic Pain, Spasticity, and Autonomic Dysreflexia.下行5-羟色胺能纤维在脊髓损伤（SCI）后病理生理学发展中的作用：对慢性疼痛、痉挛和自主神经反射异常的影响
Biology (Basel). 2022 Feb 1;11(2):234. doi: 10.3390/biology11020234.
6
Absence of a significant interaction of two common NOS1 and 5-HTT polymorphisms on sensorimotor gating in humans.两种常见的NOS1 和 5-HTT 多态性在人类感觉运动门控中无显著相互作用。
Physiol Res. 2021 Dec 31;70(S3):S387-S395. doi: 10.33549/physiolres.934819.
7
Neurological and Inflammatory Manifestations in Sjögren's Syndrome: The Role of the Kynurenine Metabolic Pathway.干燥综合征的神经和炎症表现：色氨酸代谢途径的作用。
Int J Mol Sci. 2018 Dec 8;19(12):3953. doi: 10.3390/ijms19123953.
8
Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands.5-羟色胺1A受体配体的功能选择性与抗抑郁活性
Int J Mol Sci. 2015 Aug 7;16(8):18474-506. doi: 10.3390/ijms160818474.
9
Alteration in 5-HT₂C, NMDA receptor and IP3 in cerebral cortex of epileptic rats: restorative role of Bacopa monnieri.癫痫大鼠大脑皮层中5-羟色胺2C、N-甲基-D-天冬氨酸受体和三磷酸肌醇的变化：假马齿苋的修复作用
Neurochem Res. 2015 Jan;40(1):216-25. doi: 10.1007/s11064-014-1472-2. Epub 2014 Dec 13.
10
The ascending median raphe projections are mainly glutamatergic in the mouse forebrain.在小鼠前脑中，中缝背核的上行投射主要是谷氨酸能的。
Brain Struct Funct. 2016 Mar;221(2):735-51. doi: 10.1007/s00429-014-0935-1. Epub 2014 Nov 9.

本文引用的文献

1
Effects of RO 60 0175, a 5-HT(2C) receptor agonist, in three animal models of anxiety.5-羟色胺（2C）受体激动剂RO 60 0175在三种焦虑动物模型中的作用。
Eur J Pharmacol. 2000 Jan 10;387(2):197-204. doi: 10.1016/s0014-2999(99)00706-2.
2
A review of central 5-HT receptors and their function.中枢5-羟色胺受体及其功能综述。
Neuropharmacology. 1999 Aug;38(8):1083-152. doi: 10.1016/s0028-3908(99)00010-6.
3
Actions of 5-HT on human neocortical neurones in vitro.
Brain Res. 1999 Jun 26;833(1):93-100. doi: 10.1016/s0006-8993(99)01540-1.
4
In vivo studies of the cerebral glutamate receptor/NO/cGMP pathway.大脑谷氨酸受体/一氧化氮/环磷酸鸟苷途径的体内研究
Prog Neurobiol. 1999 May;58(1):89-120. doi: 10.1016/s0301-0082(98)00077-x.
5
Electrophysiological examination of the effects of sustained flibanserin administration on serotonin receptors in rat brain.持续给予氟班色林对大鼠大脑中血清素受体影响的电生理检查。
Br J Pharmacol. 1999 Feb;126(3):627-38. doi: 10.1038/sj.bjp.0702344.
6
Pharmacological diversity between native human 5-HT1B and 5-HT1D receptors sited on different neurons and involved in different functions.位于不同神经元上且参与不同功能的天然人类5-HT1B和5-HT1D受体之间的药理学差异。
Br J Pharmacol. 1999 Feb;126(3):607-12. doi: 10.1038/sj.bjp.0702336.
7
Selective labelling of 5-HT7 receptor recognition sites in rat brain using [3H]5-carboxamidotryptamine.使用[3H]5-羧基酰胺色胺对大鼠脑中5-HT7受体识别位点进行选择性标记。
Neuropharmacology. 1998 Dec;37(12):1611-9. doi: 10.1016/s0028-3908(98)00117-8.
8
5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex.
Neuropsychopharmacology. 1999 Jan;20(1):92-6. doi: 10.1016/S0893-133X(98)00046-3.
9
5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential.
J Pharmacol Exp Ther. 1998 Aug;286(2):913-24.
10
Anxiolytic antidepressant augmentation.抗焦虑抑郁增效治疗。
J Clin Psychiatry. 1998;59 Suppl 5:42-8; discussion 49-50.

5-羟色胺对人新皮质切片中N-甲基-D-天冬氨酸受体/一氧化氮/环磷酸鸟苷途径的抑制作用：5-HT(2C)和5-HT(1A)受体的参与

Serotonin inhibition of the NMDA receptor/nitric oxide/cyclic GMP pathway in human neocortex slices: involvement of 5-HT(2C) and 5-HT(1A) receptors.

作者信息

Maura G, Marcoli M, Pepicelli O, Rosu C, Viola C, Raiteri M

机构信息

Dipartimento di Medicina Sperimentale, Sezione di Farmacologia e Tossicologia, Università di Genova, Viale Cembrano 4, 16148 Genova, Italy.

出版信息

Br J Pharmacol. 2000 Aug;130(8):1853-8. doi: 10.1038/sj.bjp.0703510.

DOI:10.1038/sj.bjp.0703510
PMID:10952674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1572268/
Abstract

The NMDA receptor/nitric oxide (NO)/cyclic GMP pathway and its modulation by 5-hydroxytryptamine (5-HT) was studied in slices of neocortical samples obtained from patients undergoing neurosurgery. The cyclic GMP elevation produced by 100 microM NMDA was blocked by 100 microM of the NO synthase inhibitor N(G)-nitro-L-arginine (L-NOARG) or by 10 microM of the soluble guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3,-alpha] quinoxaline-1-one (ODQ). The NMDA effect was prevented by 5-HT or by the 5-HT(2) agonist (+/-)-1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane ((+/-)-DOI; EC(50)=22 nM). The (+/-)-DOI inhibition was insensitive to the 5-HT(2A) receptor antagonist MDL 100907 or the 5-HT(2B) antagonist rauwolscine; it was largely prevented by 1 microM of the non-selective 5-HT(2C) antagonists mesulergine (5-HT(2A,B,C)), ketanserin (5-HT(2A,C)) or SB 200646A (5-HT(2B,C)); it was completely abolished by 0.1 microM of the selective 5-HT(2C) receptor antagonist SB 242084. The NMDA-induced cyclic GMP elevation also was potently inhibited by the selective 5-HT(2C) agonist RO 60-0175 and by the antidepressant trazodone, both added at 1 microM, in an SB 242084-sensitive manner. Finally, the 5-HT(1A) agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT; 1 microM) inhibited the NMDA-evoked cyclic GMP response, an effect blocked by the selective 5-HT(1A) receptor antagonist WAY 100635. In conclusion, the NMDA receptor/NO/cyclic GMP pathway in human neocortex slices can be potently inhibited by activation of 5-HT(2C) or 5-HT(1A) receptors.

摘要

在接受神经外科手术患者的新皮质样本切片中，研究了N-甲基-D-天冬氨酸（NMDA）受体/一氧化氮（NO）/环磷酸鸟苷（cGMP）通路及其受5-羟色胺（5-HT）的调节情况。100微摩尔的NMDA所引起的cGMP升高，被100微摩尔的NO合酶抑制剂N（G）-硝基-L-精氨酸（L-NOARG）或10微摩尔的可溶性鸟苷酸环化酶抑制剂1H-[1,2,4]恶二唑并[4,3,-α]喹喔啉-1-酮（ODQ）所阻断。5-HT或5-HT（2）激动剂（±）-1-（2,5-二甲氧基-4-碘苯基）-2-氨基丙烷（（±）-DOI；半数有效浓度（EC50）=22纳摩尔）可阻止NMDA的作用。（±）-DOI的抑制作用对5-HT（2A）受体拮抗剂MDL 100907或5-HT（2B）拮抗剂萝芙素不敏感；它在很大程度上被1微摩尔的非选择性5-HT（2C）拮抗剂美舒麦角（5-HT（2A、B、C））、酮色林（5-HT（2A、C））或SB 200646A（5-HT（2B、C））所阻止；它被0.1微摩尔的选择性5-HT（2C）受体拮抗剂SB 242084完全消除。NMDA诱导的cGMP升高也被选择性5-HT（2C）激动剂RO 60-0175和抗抑郁药曲唑酮以SB 242084敏感的方式有效抑制，二者均以1微摩尔的浓度添加。最后，5-HT（1A）激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT；1微摩尔）抑制了NMDA诱发的cGMP反应，该作用被选择性5-HT（1A）受体拮抗剂WAY 100635阻断。总之，人新皮质切片中的NMDA受体/NO/cGMP通路可被5-HT（2C）或5-HT（1A）受体的激活有效抑制。