Sussman N
Department of Psychiatry, New York University School of Medicine, New York 10021, USA.
J Clin Psychiatry. 1998;59 Suppl 5:42-8; discussion 49-50.
The administration of anxiolytic drugs often accompanies treatment with antidepressant medications. Although benzodiazepines help alleviate the secondary depressive symptoms of anxiety and sleep disturbance, they do not actually enhance antidepressant response. On the other hand, the anxiolytic agent buspirone does facilitate direct antidepressant response, largely through its ability to activate both presynaptic and postsynaptic 5-HT1A receptors and thus modulate serotonin release. Several case studies and open-label trials have demonstrated the effectiveness of buspirone as an augmentation agent. Because buspirone is also associated with few adverse effects, it appears to be both effective and safe in the augmentation of antidepressant pharmacotherapy.
抗焦虑药物的使用常常与抗抑郁药物治疗相伴。尽管苯二氮䓬类药物有助于缓解焦虑和睡眠障碍的继发性抑郁症状，但它们实际上并不能增强抗抑郁反应。另一方面，抗焦虑药物丁螺环酮确实能促进直接的抗抑郁反应，这主要是通过其激活突触前和突触后5-HT1A受体从而调节血清素释放的能力实现的。多项病例研究和开放标签试验已证明丁螺环酮作为增效剂的有效性。由于丁螺环酮的不良反应也较少，它在增强抗抑郁药物治疗方面似乎既有效又安全。
