Langman M J
Department of Medicine, University of Birmingham, UK.
Baillieres Best Pract Res Clin Gastroenterol. 2000 Jun;14(3):357-64. doi: 10.1053/bega.2000.0084.
Despite many clinical investigations, proof is lacking that pharmacological treatments significantly influence the outcome in non-variceal upper gastrointestinal bleeding. Reaching conclusions has been hindered by the small size of many studies in a situation in which a large number of patients must be included if confident conclusions are to be reached. In addition, many studies, by comparing two potentially active treatments without a placebo group, have been unable to determine whether an equivalence of the active treatments represents equivalent but active or equivalent but inactive therapy.
尽管进行了许多临床研究，但仍缺乏证据表明药物治疗能显著影响非静脉曲张性上消化道出血的结局。许多研究规模较小，这阻碍了得出结论，因为在这种情况下，若要得出可靠结论，必须纳入大量患者。此外，许多研究在比较两种可能有效的治疗方法时未设安慰剂组，因而无法确定有效治疗方法之间的等效性是代表等效但有效的治疗还是等效但无效的治疗。
