Langman M J
Dept. of Medicine, Queen Elizabeth Hospital, Birmingham, U.K.
Scand J Gastroenterol Suppl. 1988;146:185-90.
It is plausible that, for pharmacologic and physiologic reasons, antisecretory treatment reduces the chances of rebleeding from gastric and duodenal ulcers and thereby reduces operation and death rates. Currently available evidence is not strong enough to confirm this, in part because trials have been too small to detect any differences present, and perhaps in part because drug doses have been too low to achieve the desired antisecretory potential.
从药理学和生理学角度来看，抗分泌治疗能够降低胃和十二指肠溃疡再出血的几率，进而降低手术率和死亡率，这似乎是合理的。目前可得的证据还不够有力，无法证实这一点，部分原因在于试验规模过小，难以检测到存在的差异，或许还部分因为药物剂量过低，无法实现所需的抗分泌潜能。
