Sokolík J, Tumová I, Blahová M, Danková M, Svec P
Katedra chemickej teórie lieciv a Katedra farmakológie a toxikológie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Ceska Slov Farm. 2000 Jul;49(4):203-5.
Using rat paw dextran-induced and carrageenan-induced edemas, the antiedematous activities of dihydrate of diaquatetrakis(p-cresotato)dicopper(II) complex (CupC) and diaquabis(p-cresotato)zinc(II) complex (ZnpC) were assayed plethysmometrically. Dihydrate of diaquabis(salicylato)copper(II) complex (CuS) and diaquabis(salicylato)zinc(II) complex (ZnS) were used as standards of comparison. All compounds were applied i.p. in a single dose of 50 mumol/kg body weight (calculated for the RCOO-fragment) 30 min before injecting the irritant. The antidextran/anticarrageenan activities of the species (expressed as a mean edema reduction) were found: CupC 46/74%--ZnpC 50/26%--CuS 71/52%--ZnS 63/10%. The relationships between the coordination-chemical properties and the biological effects of the corresponding complexes are discussed.
利用大鼠足趾右旋糖酐诱导的水肿和角叉菜胶诱导的水肿，采用体积描记法测定了二水四（对甲酚根）二铜（II）配合物（CupC）和二水双（对甲酚根）锌（II）配合物（ZnpC）的抗水肿活性。二水双（水杨酸根）铜（II）配合物（CuS）和二水双（水杨酸根）锌（II）配合物（ZnS）用作对照标准。在注射刺激剂前30分钟，所有化合物均以50 μmol/kg体重的单剂量腹腔注射（按RCOO-片段计算）。发现各物质的抗右旋糖酐/抗角叉菜胶活性（以平均水肿减轻表示）如下：CupC 46/74%--ZnpC 50/26%--CuS 71/52%--ZnS 63/10%。讨论了相应配合物的配位化学性质与生物学效应之间的关系。
