Sokolík J, Karovicová K, Tumová I, Blahová M, Svec P
Katedra chemickej teórie lieciv Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Ceska Slov Farm. 1998 May;47(3):138-40.
Using rat paw dextran-induced and carrageenan-induced edemas, the anti-inflammatory activity of gallic acid (I), triacetylgallic acid (II) and monohydrate copper(II) triacetylgallate (III) was assayed. All compounds tested were applied i.p. in a single dose of 50 mumol/kg body weight, calculated for the RCOO-fragment. The average antiedematous activities in dextran/carrageenan edemas were decreasing in the following order: III (55.9/41.8%) > I (38.6/31.1%) > II (-3.4/13.3%). The relationship between the biological effects found and gallic acid as well as its structural derivatives is discussed.
利用大鼠足趾右旋糖酐诱导型和角叉菜胶诱导型水肿，测定了没食子酸（I）、三乙酰没食子酸（II）和三水合三乙酰没食子酸铜（II）（III）的抗炎活性。所有受试化合物均以50 μmol/kg体重的单剂量腹腔注射给药，以RCOO-片段计算。在右旋糖酐/角叉菜胶性水肿中，平均抗水肿活性按以下顺序降低：III（55.9/41.8%）> I（38.6/31.1%）> II（-3.4/13.3%）。讨论了所发现的生物学效应与没食子酸及其结构衍生物之间的关系。
