Sciacca P, Benini B, Marinelli C, Borrello M, Massi G
Divisione di Chirurgia Generale Urgenza e Pronto Soccorso, Azienda Ospedaliera, San Camillo Forlanini, Roma.
Minerva Chir. 2000 May;55(5):307-12.
Male breast cancer is a rare type of neoplasm, being 1% of all breast tumors. An increasing relevance is given to genetic factors. Familiarity is present in 10% of cases reported in literature. Gynecomastia is frequently associated. Personal experience about this pathology is compared with the most recent data of the literature.
Nine cases of male breast cancer observed among 519 breast tumors operated between 1982 and 1997 are reported. Etiologic and prognostic aspects, surgical and complementary therapy of breast cancer in man are examined and the high rate of II-III stage patients, mostly ER+ and PR+ is underlined. Diagnosis is reached by ultrasonography and mammography, after an accurate clinical examination and confirmed by cytology after needle biopsy. The choice operation is total mastectomy with axillary lymphadenectomy according to Patey.
According to our experience, 5 patients died for non neoplastic pathology, 1 patient lost at follow-up, 3 patients still alive after 66, 60 and 12 months respectively.
Male breast cancer is similar to the female one, but characterized by a higher hormone receptors positivity. Our survival data have no statistic significance. It is still discussed if prognostic difference between men and women is present or not.
男性乳腺癌是一种罕见的肿瘤类型，占所有乳腺肿瘤的1%。遗传因素的相关性日益增加。文献报道的病例中有10%存在家族性。男性乳腺增生症常与之相关。将本人关于这种疾病的经验与最新的文献数据进行比较。
报告了1982年至1997年间在519例接受手术的乳腺肿瘤中观察到的9例男性乳腺癌病例。研究了男性乳腺癌的病因和预后方面、手术及辅助治疗情况，并强调了II-III期患者的高比例，其中大多数为雌激素受体（ER）阳性和孕激素受体（PR）阳性。通过准确的临床检查后，经超声和乳腺X线摄影进行诊断，并在针吸活检后经细胞学检查确诊。根据佩蒂（Patey）方法，选择的手术方式为全乳切除加腋窝淋巴结清扫术。
根据我们的经验，5例患者死于非肿瘤性疾病，1例患者失访，3例患者分别在66个月、60个月和12个月后仍存活。
男性乳腺癌与女性乳腺癌相似，但具有更高的激素受体阳性率。我们的生存数据无统计学意义。男性和女性之间是否存在预后差异仍在讨论中。
