Martín Alvarez H, Plaza Cano M, Estirado de Cabo E, García de Aguinaga M, Izquierdo Martínez M, Posada de la Paz M
Centro de Investigación para el Sindrome del Aceite Tóxico (CISAT), Instituto de Salud Carlos III, Madrid.
Rev Clin Esp. 2000 Jun;200(6):305-9. doi: 10.1016/s0014-2565(00)70642-4.
To report the symptoms and analytical findings observed in the collective of patients affected with the toxic oil syndrome (TOS) 18 years after the poisoning.
At the Centro de Investigación sobre el Síndrome del Aceite Tóxico (CISAT) we followed the clinical and analytical course of 758 patients affected with the TOS since December 1997 up to May 1999. Patients were evaluated by means of a previously standardized questionnaire in which a clinical review and a battery of complementary tests (thyroid hormones, spirometry with diffusion test and arterial gasometry) were included. One hundred and sixty-two patients underwent also echocardiogram because of presumptive pulmonary hypertension and/or heart disease.
Out of the 758 patients, 516 were females and 242 males (M:F ratio 2:1), with ages ranging from 17 to 84 years (mean age 47 years). One of the most remarkable findings was the increased prevalence of cardiovascular risk factors: arterial hypertension (34%), dyslipemias (44%), overweight (40%), obesity (27%), carbohydrate intolerance (9%) and diabetes mellitus (9.4%). The most common reported symptoms were: cramps (78%), arthralgias (78%), and paresthesias (70%). Only 2.8% of patients reported to be asymptomatic. The analytical results most commonly changed were: changes in lipidic and carbohydrate metabolism (already reported), overt or subclinical hypothyroidism (6.6%) and respiratory changes in patients with no previous pulmonary disease: changes in spirometry (6%), diffusion test (8%) and hypoxemia (18%). Echocardiographic findings suggestive of PHT were obtained in 3.1% of cases.
Although TOS occurred in 1981, this syndrome still has a relevant morbidity in a portion of the spanish population. To remark the high prevalence of cardiovascular risk factors with changes in lipidic and carbohydrate metabolism and subclinical hypothyroidism observed in our series. Further studies are necessary to evaluate the actual dimension of this poisoning.
报告中毒18年后中毒性油综合征（TOS）患者群体中观察到的症状及分析结果。
在中毒性油综合征研究中心（CISAT），我们追踪了自1997年12月至1999年5月期间758例TOS患者的临床及分析过程。通过一份预先标准化的问卷对患者进行评估，问卷包括临床检查及一系列补充检查（甲状腺激素、肺功能及弥散试验和动脉血气分析）。162例患者因疑似肺动脉高压和/或心脏病还接受了超声心动图检查。
758例患者中，女性516例，男性242例（男女比例为2:1），年龄在17至84岁之间（平均年龄47岁）。最显著的发现之一是心血管危险因素患病率增加：动脉高血压（34%）、血脂异常（44%）、超重（40%）、肥胖（27%）、碳水化合物不耐受（9%）和糖尿病（9.4%）。报告最多的常见症状为：痉挛（78%）、关节痛（78%）和感觉异常（70%）。仅2.8%的患者报告无症状。最常出现变化的分析结果为：脂质和碳水化合物代谢变化（已报告）、显性或亚临床甲状腺功能减退（6.6%）以及既往无肺部疾病患者的呼吸变化：肺功能变化（6%）、弥散试验变化（8%）和低氧血症（18%）。3.1%的病例获得提示肺动脉高压的超声心动图结果。
尽管TOS于1981年发生，但该综合征在部分西班牙人群中仍具有相当的发病率。需注意我们的系列研究中观察到的心血管危险因素高患病率以及脂质和碳水化合物代谢变化及亚临床甲状腺功能减退。有必要进行进一步研究以评估此次中毒的实际影响范围。
