García de Aguinaga María Luisa, Posada de la Paz Manuel, Estirado de Cabo Eva, Plaza Cano María del Mar, Alvarez Carmen Suárez, Saro Beatriz Braun, Abaitua Borda Ignacio, Sánchez Rafael Gabriel, Barbado Hernández Francisco Javier
Toxic Oil Syndrome Research Unit, Rare Diseases Research Institute, Instituto de Salud Carlos III, Spain.
Eur J Intern Med. 2008 Jan;19(1):32-9. doi: 10.1016/j.ejim.2007.04.018. Epub 2007 Sep 18.
The objective of this study was to compare current prevalence of major cardiovascular risk factors (CRF) between a cohort of patients affected by the toxic oil syndrome (TOS) epidemic, which occurred in Spain in 1981, and the unaffected Spanish population.
This was a case-referent study covering 1276 TOS cases and a referent population of 2843 (aged 35-65 years) using data collected from 1996 to 2003. Study variables were high blood pressure, hyperglycemia, dyslipemia, obesity, and metabolic syndrome. Smoking habit, alcohol intake, family and personal history of ischemic heart disease, as well as a personal history of cerebrovascular disease were also assessed in TOS patients.
Compared to the general population, TOS patients registered a threefold rise in prevalence of diabetes, a 2.57-fold increase in hypertension, a 1.38-fold increase in total hypercholesterolemia, a 1.20-fold increase in hyper-LDL-cholesterolemia, and a high prevalence of metabolic syndrome (35% versus 25%). Nevertheless, the prevalence of hypo-HDL-cholesterolemia was significantly lower in those affected by TOS. No differences were found for other CRFs.
Compared to the general population, cases display a much higher prevalence of all major CRFs. However, an increase in HDL-cholesterol protective factor is in evidence for the first time.
本研究的目的是比较1981年发生在西班牙的有毒食用油综合征（TOS）流行的患者队列与未受影响的西班牙人群之间主要心血管危险因素（CRF）的当前流行率。
这是一项病例对照研究，使用1996年至2003年收集的数据，涵盖1276例TOS病例和2843名（年龄在35 - 65岁之间）对照人群。研究变量包括高血压、高血糖、血脂异常、肥胖和代谢综合征。还评估了TOS患者的吸烟习惯、酒精摄入量、缺血性心脏病的家族和个人病史以及脑血管疾病的个人病史。
与普通人群相比，TOS患者的糖尿病患病率上升了两倍，高血压患病率增加了2.57倍，总胆固醇血症患病率增加了1.38倍，高LDL - 胆固醇血症患病率增加了1.20倍，代谢综合征患病率较高（35%对25%）。然而，TOS患者的低HDL - 胆固醇血症患病率显著较低。其他CRF未发现差异。
与普通人群相比，病例显示所有主要CRF的患病率要高得多。然而，首次有证据表明HDL胆固醇保护因子增加。
