Fukusaki C, Kawakubo K, Yamamoto Y
Educational Physiology Laboratory, Graduate School of Education, The University of Tokyo, Japan.
Clin Auton Res. 2000 Jun;10(3):123-30. doi: 10.1007/BF02278016.
Beat-to-beat heart rate variability (HRV), reflecting cardiac autonomic control mechanisms, is known to change with age. However, the degree to which this change is mediated by aging per se or by physiologic changes characteristic of normative aging is still unclear. This study was designed to examine the association of aerobic fitness, body habitus or obesity, and blood pressure with age-related changes in HRV. Resting HRV data was recorded from 373 healthy subjects (124 men, 249 women; age range, 16-69 y) and analyzed by coarse-graining spectral analysis to decompose the total spectral power into its harmonic and fractal components. The low- and high-frequency (LF, 0.0-0.15 Hz; HF, >0.15 Hz) harmonic components were calculated from the former, whereas the latter was used to calculate the integrated power (FR) and the spectral exponent , beta, which were, in turn, used to evaluate the overall complexity of HRV. Factor analysis was performed to test whether potentially age-related changes in the components of HRV might be observed secondarily through other variables affecting HRV. Significant (p <0.05) age-related changes in the harmonic (HF and LF) and fractal (FR and beta) components of HRV were generally consistent with those described in the literature. In addition, factor analysis showed that there was a unique common factor that primarily explained correlations among age, HF, and beta (p <0.05) without the contributions from LF, FR, aerobic fitness, body habitus or obesity, and blood pressure. It was concluded that, in this population-based sample, age-related changes in HF and beta, both of which reflect vagal modulation of heart rate, were primarily mediated by aging per se and not by physiologic changes characteristic of normative aging.
逐搏心率变异性（HRV）反映心脏自主控制机制，已知其会随年龄变化。然而，这种变化在多大程度上是由衰老本身介导的，还是由正常衰老的生理变化介导的，目前仍不清楚。本研究旨在探讨有氧适能、身体形态或肥胖以及血压与HRV的年龄相关变化之间的关联。记录了373名健康受试者（124名男性，249名女性；年龄范围16 - 69岁）的静息HRV数据，并通过粗粒化频谱分析进行分析，将总频谱功率分解为谐波和分形成分。从前者计算低频和高频（LF，0.0 - 0.15Hz；HF，>0.15Hz）谐波成分，而后者用于计算积分功率（FR）和频谱指数β，进而用于评估HRV的整体复杂性。进行因子分析以测试是否可能通过影响HRV的其他变量继发观察到HRV各成分中潜在的年龄相关变化。HRV谐波（HF和LF）和分形（FR和β）成分中显著（p<0.05）的年龄相关变化总体上与文献中描述的一致。此外，因子分析表明存在一个独特的共同因子，主要解释年龄、HF和β之间的相关性（p<0.05），而不受LF、FR、有氧适能、身体形态或肥胖以及血压的影响。得出的结论是，在这个基于人群的样本中，HF和β的年龄相关变化，这两者都反映了心率的迷走神经调节，主要是由衰老本身介导的，而不是由正常衰老的生理变化介导的。
