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在分离的沙鼠胰腺胰岛中，葡萄糖和精氨酸刺激后出现的反常胰高血糖素反应。

Paradoxical glucagon response after stimulation with glucose and arginine in isolated pancreatic sand rat islets.

作者信息

Ziegler M, Hahn H J, Ziegler B, Köhler E, Fiedler H

出版信息

Diabetologia. 1975 Feb;11(1):63-9. doi: 10.1007/BF00422820.

DOI:10.1007/BF00422820
PMID:1095440
Abstract

Isolated pancreatic islets of normoglycemic sand rats do not respond to 2.5 mM glucose with an enhanced glucagon secretion, which could be observed in normal Wistar rats. Arginine stimulates glucagon release in the presence of 2.5 mM glucose in Wistar rats as well as in sand rats. The secretion pattern is not caused by insulin deficiency since sand rat islets are characterized by an increased insulin secretion rate in vitro. This paradoxical glucagon secretion is not caused by a changed glucagon content but might be related to this species which is able to develop a diabetic syndrome spontaneously.

摘要

正常血糖沙鼠的分离胰岛对2.5 mM葡萄糖不产生胰高血糖素分泌增强的反应，而在正常Wistar大鼠中可以观察到这种反应。精氨酸在2.5 mM葡萄糖存在的情况下能刺激Wistar大鼠和沙鼠的胰高血糖素释放。这种分泌模式不是由胰岛素缺乏引起的，因为沙鼠胰岛的特点是在体外胰岛素分泌率增加。这种矛盾的胰高血糖素分泌不是由胰高血糖素含量的改变引起的，而是可能与该物种能够自发发展为糖尿病综合征有关。

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本文引用的文献

1
Preparation of iodine-131 labelled human growth hormone of high specific activity.高比活度碘-131标记人生长激素的制备
Nature. 1962 May 5;194:495-6. doi: 10.1038/194495a0.
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An investigation of glucagon biosynthesis in isolated pancreatic islets of guinea pigs.豚鼠分离胰岛中胰高血糖素生物合成的研究。
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[The effects of perfusion and amino acid ingestion in glucagonenemia].[胰高血糖素血症中灌注和氨基酸摄入的影响]
Diabetologia. 1976 Aug;12(4):301-6. doi: 10.1007/BF00420972.
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Organ culture of fetal rat pancreas. II. Insulin release induced by amino and organic acids, by hormonal peptides, by cationic alterations of the medium and by other agents.胎鼠胰腺的器官培养。II. 氨基酸、有机酸、激素肽、培养基阳离子改变及其他试剂诱导的胰岛素释放。
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Control of pancreatic glucagon secretion by glucose.葡萄糖对胰腺胰高血糖素分泌的调控
Diabetes. 1969 Jan;18(1):1-10. doi: 10.2337/diab.18.1.1.
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Effect of blood glucose on glucagon secretion in anesthetized dogs.血糖对麻醉犬胰高血糖素分泌的影响。
Diabetes. 1969 Jan;18(1):11-8. doi: 10.2337/diab.18.1.11.
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[Report on a rapid enzyme technic for the determination of blood sugar in 5 microliters of capillary blood without protein separation and without centrifugation].[关于一种无需分离蛋白质和离心即可测定5微升毛细血管血中血糖的快速酶技术的报告]
Klin Wochenschr. 1968 Jul 15;46(14):789-90. doi: 10.1007/BF01745496.
10
Characterization of response of circulating glucagon to intraduodenal and intravenous administration of amino acids.循环胰高血糖素对十二指肠内和静脉注射氨基酸反应的特征分析。
J Clin Invest. 1968 Oct;47(10):2305-22. doi: 10.1172/JCI105916.