环氧二十碳三烯酸刺激离体大鼠胰岛释放胰高血糖素和胰岛素。
Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets.
作者信息
Falck J R, Manna S, Moltz J, Chacos N, Capdevila J
出版信息
Biochem Biophys Res Commun. 1983 Jul 29;114(2):743-9. doi: 10.1016/0006-291x(83)90843-4.
PMID:6411091
Abstract
Metapyrone and eicosatetraynoic acid but not indomethacin are effective inhibitors of the secretory response of isolated rat pancreatic islets to arginine and glucose. Epoxyeicosatrienoic acids, products of the cytochrome P-450-NADPH dependent arachidonic acid epoxygenase activity, are potent and selective mediators for the in vitro release of either insulin or glucagon from preparations of isolated rat pancreatic islets.
摘要
甲吡酮和二十碳四炔酸而非吲哚美辛是分离的大鼠胰岛对精氨酸和葡萄糖分泌反应的有效抑制剂。环氧二十碳三烯酸是细胞色素P-450-依赖烟酰胺腺嘌呤二核苷酸磷酸的花生四烯酸环氧化酶活性的产物，是从分离的大鼠胰岛制剂中体外释放胰岛素或胰高血糖素的强效且选择性介质。
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