Janssens W, Salminen M O, Laukkanen T, Heyndrickx L, Colebunders R, McCutchan F E, van der Groen G
Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium.
AIDS Res Hum Retroviruses. 2000 Aug 10;16(12):1183-9. doi: 10.1089/088922200415045.
HIV-1 CRF02.AG strains are prevalent in west and west-central Africa, suggesting a longstanding presence of these subtype A/G recombinants in the global epidemic. Cocirculation of CRF02.AG strains with other group M subtypes may give rise to HIV-1 recombinants constituting a mosaic genome comprising fragments of three different subtypes. We report on the genetic analysis of the near-full-length genomes of such recombinants (VI1035 and VI1197) as well as CRF02.AG strains in Belgian individuals. VI1035 and VI1197 may be the result of successful "second-generation" recombinations of HIV-1 strains CRF02.AG with, respectively, subtype C (VI1035) and G (VI1197) strains in a dually infected individual.
HIV-1 CRF02.AG毒株在西非和中西部非洲流行，这表明这些A/G亚型重组毒株在全球疫情中已长期存在。CRF02.AG毒株与其他M组亚型共同流行，可能会产生HIV-1重组毒株，其镶嵌基因组由三种不同亚型的片段组成。我们报告了对比利时个体中此类重组毒株（VI1035和VI1197）以及CRF02.AG毒株的近全长基因组的遗传分析。VI1035和VI1197可能分别是HIV-1毒株CRF02.AG与双重感染个体中的C亚型（VI1035）和G亚型（VI1197）毒株成功进行“第二代”重组的结果。
