影响白色念珠菌丝状体形成的因素：白色念珠菌在丝状体形成过程中呼吸活性的变化。
Factors affecting filamentation in Candida albicans: changes in respiratory activity of Candida albicans during filamentation.
作者信息
Land G A, McDonald W C, Stjernholm R L, Friedman L
出版信息
Infect Immun. 1975 Jul;12(1):119-27. doi: 10.1128/iai.12.1.119-127.1975.
Abstract
Glucose metabolism and respiration of Candida albicans were compared under conditions which permitted either maximal filamentous or maximal yeast growth. Changes in metabolism were monitored by comparing the quantities of ethanol produced, CO2 evolved, and oxygen consumed. Filamenting cultures produced more ethanol and less CO2 than yeasts, with oxygen consumption in the former concomitantly slower than that of the latter. Studies involving cofactors and inhibitors associated with electron transport imply that a transfer of electrons away from flavoprotein is required for maintenance of yeast morphology. Conditions consistent with a buildup of reduced flavoprotein, however, favored filament formation. These changes were expressed metabolically as a shift from an aerobic to a fermentative metabolism. The results presented are consistent with hypotheses correlating filament production with changes in carbohydrate metabolism and an interruption of electron transfer within the cell.
摘要
在允许白色念珠菌最大程度丝状生长或最大程度酵母生长的条件下，对其葡萄糖代谢和呼吸作用进行了比较。通过比较产生的乙醇量、释放的二氧化碳量和消耗的氧量来监测代谢变化。丝状培养物比酵母产生更多的乙醇和更少的二氧化碳，前者的耗氧量也比后者慢。涉及与电子传递相关的辅助因子和抑制剂的研究表明，为维持酵母形态，电子需要从黄素蛋白转移出去。然而，与还原型黄素蛋白积累相一致的条件有利于丝状形成。这些变化在代谢上表现为从有氧代谢向发酵代谢的转变。所呈现的结果与将丝状产生与碳水化合物代谢变化以及细胞内电子传递中断相关联的假设一致。
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