Kane R, Finlay D, Lamb T, Martin F
Dept. of Pharmacology, University College Dublin, Belfield, Ireland.
Adv Exp Med Biol. 2000;480:117-22. doi: 10.1007/0-306-46832-8_14.
Transcripts of each of the four NF1 genes (NF1 A, B, C (CTF/NF1) and X) are expressed in both lactating and involuting mouse mammary gland but there is an indication that increased expression of an NF1 C (CTF/NF1) transcript accompanies early involution. The involution-associated 74 kD NF1 and the 114 kD lactation-associated NF1 are recognised by an anti-NF1 C-specific antibody that does not cross-react with other NF1 proteins. It is most likely that this lactation/involution switch in NF1 factors represents a change in expression of NF1 C (CTF/NF1) proteins.
四种NF1基因（NF1 A、B、C（CTF/NF1）和X）的转录本在泌乳期和退化期的小鼠乳腺中均有表达，但有迹象表明，NF1 C（CTF/NF1）转录本的表达增加与早期退化有关。一种抗NF1 C特异性抗体可识别与退化相关的74 kD NF1和与泌乳相关的114 kD NF1，该抗体与其他NF1蛋白无交叉反应。很可能NF1因子中的这种泌乳/退化转换代表了NF1 C（CTF/NF1）蛋白表达的变化。
