Kitamura K, Kikuchi Y, Watanabe S, Waechter G, Sakurai H, Takada T
Department of Applied Bioscience, Tokyo University of Agriculture, Japan.
J Epidemiol. 2000 Jul;10(4):262-70. doi: 10.2188/jea.10.262.
A national survey of polychlorinated dibenzo-p-dioxins (PCDD) and dibenzofurans (PCDF) in emission gases from the municipal waste incinerators in 1997 revealed that the Nose Bika Center was heavily contaminated by PCDF. Ninety-four workers underwent a physical examination, and blood biochemistry, lymphocyte marker, and NK activity studies were carried out, along with blood dioxin measurements. Information on working history, life-style, and dietary habits was obtained by questionnaire and interview. The blood dioxin levels were as follows. The median TEQ of dioxins was 39.7 pg I-TEQ/g lipid, and the range was 13.3 to 805.8. The median 2,3,7,8-TCDD concentration was 3.9 pg TEQ/g lipid, and the range was <1 pg TEQ/g lipid (one case) to 13.4 pg TEQ/g lipid. The median TEQ of coplanar PCB was 10.8 pg I-TEQ/g lipid, and the range was 3.1 to 54.2 pg TEQ/g lipid. The congener-specific distribution was quite similar to that in soil around incinerator and waste in the factory. The relationship between dioxin concentrations and work history in the factory showed that the fluidized incinerator and fly ash treatment areas were high-risk work areas. Correlation analyses between body burden, PCDD/PCDF TEQ, Co-PCB TEQ and various laboratory data showed significant positive correlations between dioxin levels and GGT, total protein, uric acid and calcium, and a negative correlation with Fe. However, these correlations disappeared as a result of multivariate analysis adjusted for age, smoking status, and alcohol drinking. Increased NK activity and lower response to PHA stimulation remained significant even after adjusting for age. History of hyperlipidemia and allergy had significantly increased odds ratios. A study on the risk to other workers in the same type of incinerators is under way. Health effects of chronic exposure mainly to PCDF will be clarified by follow-up.
1997年对城市垃圾焚烧炉排放气体中的多氯二苯并对二恶英（PCDD）和二苯并呋喃（PCDF）进行的一项全国性调查显示，鼻比卡中心受到PCDF的严重污染。94名工人接受了体格检查，并进行了血液生化、淋巴细胞标志物和NK活性研究，同时还测量了血液中的二恶英含量。通过问卷调查和访谈获取了工作史、生活方式和饮食习惯等信息。血液二恶英水平如下。二恶英的中位毒性当量（TEQ）为39.7皮克国际毒性当量/克脂质，范围为13.3至805.8。2,3,7,8 - TCDD的中位浓度为3.9皮克毒性当量/克脂质，范围为<1皮克毒性当量/克脂质（1例）至13.4皮克毒性当量/克脂质。共平面多氯联苯的中位TEQ为10.8皮克国际毒性当量/克脂质，范围为3.1至54.2皮克毒性当量/克脂质。同类物的具体分布与焚烧炉周围土壤和工厂废弃物中的分布非常相似。二恶英浓度与工厂工作史之间的关系表明，流化床焚烧炉和飞灰处理区域是高风险工作区域。对身体负荷、PCDD/PCDF TEQ、共平面多氯联苯TEQ与各种实验室数据进行的相关性分析显示，二恶英水平与γ-谷氨酰转移酶（GGT）、总蛋白、尿酸和钙之间存在显著正相关，与铁存在负相关。然而，在对年龄、吸烟状况和饮酒情况进行多变量分析后，这些相关性消失了。即使在调整年龄后，NK活性增加和对PHA刺激的反应降低仍然显著。高脂血症和过敏史的比值比显著增加。目前正在对同一类型焚烧炉中的其他工人进行风险研究。通过随访将阐明主要长期接触PCDF对健康的影响。
