Commenges D, Scotet V, Renaud S, Jacqmin-Gadda H, Barberger-Gateau P, Dartigues J F
Institut National de la Santé et de la Recherche Médicale U330, Bordeaux, France.
Eur J Epidemiol. 2000 Apr;16(4):357-63. doi: 10.1023/a:1007614613771.
It has been postulated that oxidative stress may play a key role in dementia. This is substantiated by the recent discovery of the protective effect of wine. In wine, the flavonoids--powerful antioxidant substances also contained in tea, fruits and vegetables--have been thought to offer such protection. We investigated whether flavonoid intake could be associated with a lower incidence of dementia in a cohort of 1367 subjects above 65 years of age (Paquid). A questionnaire was used to evaluate their intake of flavonoids and subjects were followed-up for 5 years between 1991 and 1996: 66 incident cases of dementia were observed. We estimated the relative risk (RR) of dementia according to tertiles of flavonoid intake using a Cox model. The age-adjusted RR of dementia was 0.55 for the two highest tertiles compared to the lowest (95% CI: 0.34-0.90; p = 0.02). After additional adjustment for gender, education, weight and vitamin C intake, the RR was 0.49 (95% CI: 0.26-0.92; p = 0.04). We conclude that the intake of antioxidant flavonoids is inversely related to the risk of incident dementia.
据推测，氧化应激可能在痴呆症中起关键作用。葡萄酒具有保护作用这一最新发现证实了这一点。葡萄酒中含有类黄酮，茶、水果和蔬菜中也含有这种强大的抗氧化物质，人们认为这些物质具有这种保护作用。我们调查了1367名65岁以上的受试者（Paquid队列）中，类黄酮摄入量是否与较低的痴呆症发病率相关。通过问卷调查来评估他们类黄酮的摄入量，并在1991年至1996年期间对受试者进行了5年的随访：观察到66例痴呆症发病病例。我们使用Cox模型根据类黄酮摄入量的三分位数估计痴呆症的相对风险（RR）。与最低三分位数相比，最高的两个三分位数的痴呆症年龄调整RR为0.55（95%可信区间：0.34 - 0.90；p = 0.02）。在对性别、教育程度、体重和维生素C摄入量进行进一步调整后，RR为0.49（95%可信区间：0.26 - 0.92；p = 0.04）。我们得出结论，抗氧化类黄酮的摄入量与新发痴呆症的风险呈负相关。
