Ji Y, Urakami K, Adachi Y, Maeda M, Isoe K, Nakashima K
Division of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan.
Dement Geriatr Cogn Disord. 1998 Sep-Oct;9(5):243-5. doi: 10.1159/000017068.
Apolipoprotein E sigma4 allele (ApoE sigma4) is associated with Alzheimer's disease (AD) in familial and sporadic cases, but the associations of ApoE sigma4 allele and vascular dementia (VD) and/or ischemic cerebrovascular disease (ICVD) are still controversial. To clarify the associations of ApoE polymorphism with AD, VD and ICVD in Japanese, we examined ApoE polymorphism in samples of 255 patients with AD, 87 patients with VD, and 123 patients with ICVD, as compared with 117 age-matched healthy control subjects (CTL). The frequency of the ApoE sigma4 allele was significantly higher in the VD group (0.21), the ICVD group (0.15) as well as in the AD group (0. 26) than in the CTL subjects (0.08). These findings suggest that the genotype of ApoE sigma4 is associated with not only AD but also VD and ICVD, and that ApoE sigma4 plays an important role in the development of dementia and ICVD.
载脂蛋白Eε4等位基因（ApoEε4）在家族性和散发性阿尔茨海默病（AD）病例中均与该病相关，但ApoEε4等位基因与血管性痴呆（VD）和/或缺血性脑血管病（ICVD）之间的关联仍存在争议。为明确日本人群中ApoE基因多态性与AD、VD和ICVD的关系，我们检测了255例AD患者、87例VD患者和123例ICVD患者样本中的ApoE基因多态性，并与117例年龄匹配的健康对照者（CTL）进行比较。VD组（0.21）、ICVD组（0.15）以及AD组（0.26）中ApoEε4等位基因的频率均显著高于CTL组（0.08）。这些发现提示，ApoEε4基因型不仅与AD相关，还与VD和ICVD相关，且ApoEε4在痴呆和ICVD的发生发展中起重要作用。
