神经性贪食症和神经性厌食症（贪食亚型）康复后的脑脊液中催产素和加压素水平。
CSF oxytocin and vasopressin levels after recovery from bulimia nervosa and anorexia nervosa, bulimic subtype.
作者信息
Frank G K, Kaye W H, Altemus M, Greeno C G
机构信息
Department of Psychiatry, University of Pittsburgh, School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA.
出版信息
Biol Psychiatry. 2000 Aug 15;48(4):315-8. doi: 10.1016/s0006-3223(00)00243-2.
BACKGROUND
When ill, people with eating disorders have disturbances of the neuropeptides vasopressin and oxytocin.
METHODS
To avoid the confounding effects of the ill state, we studied women who were recovered (more than 1 year, normal weight, and regular menstrual cycles, no bingeing or purging) from bulimia nervosa (rBN) or binge eating/purging-type anorexia nervosa (rAN-BN), and matched healthy control women.
RESULTS
Vasopressin was elevated in rAN-BN and showed a trend towards elevation in rBN. In rBN, elevated cerebrospinal fluid vasopressin may be related to having a lifetime history of major depression. In comparison, cerebrospinal fluid oxytocin was normal in recovered subjects, but elevated levels in some rBN might be related to birth control pill use.
CONCLUSIONS
These data confirm and extend the possibility that elevated cerebrospinal fluid vasopressin may be related to the pathophysiology of eating disorders, and/or a lifetime history of major depression.
背景
患有饮食失调症的人在生病时会出现神经肽血管加压素和催产素的紊乱。
方法
为避免患病状态的混杂影响，我们研究了从神经性贪食症（rBN）或暴饮暴食/清除型神经性厌食症（rAN-BN）康复的女性（超过1年，体重正常，月经周期规律，无暴饮暴食或清除行为），并与健康对照女性进行匹配。
结果
rAN-BN中血管加压素升高，rBN中有升高趋势。在rBN中，脑脊液血管加压素升高可能与有重度抑郁症的终生病史有关。相比之下，康复受试者的脑脊液催产素正常，但一些rBN中的升高水平可能与使用避孕药有关。
结论
这些数据证实并扩展了脑脊液血管加压素升高可能与饮食失调症的病理生理学和/或重度抑郁症的终生病史有关的可能性。
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