Krakhmal'nikova G Kh, Zarubina N A, Gracheva L I, Lomovitskaia T S, Teplitskaia O L
Probl Endokrinol (Mosk). 1975 May-Jun;21(3):49-55.
Fifty five patients with cerebral and hypophyseal nanism and Shereshevsky-Turner syndrome were examined for toxoplasmosis. The diagnosis of toxoplasmosis was established on the basis of epidemiological and obstetrical anamnesis, clinical and roentgenological data and serological tests (complement fixation test in 2 modifications--by common and droplet method; precipitation test, fluorescent antibody test) and intradermal allergic test with toxoplasmin (ATT). Of 48 patients with cerebral and hypophyseal nanism ATT proved to be positive in 17 (35.4 per cent); it was positive in 3 of 7 patients with Shereshevsky-Turner syndrome. In some of the patients and their mothers serological tests for toxoplasmosis were also positive. Thus, toxoplasmosis infection among the patients examined was 2.5-3 times more incident than the corresponding indices in healthy children. It is supposed that there is pathology of hypothalamic regulation of hypophyseal functions in toxoplasmosis and nanism. A possibility of pathology of the generative apparatus in maternal toxoplasmosis leading to development of chromosomal embryopathies could not be excluded. The authors consider that further studies are necessary for ascertaining (in some of the cases) of the pathogenetic association between toxoplasmosis and growth and developmental disturbances.
对55例脑垂体性侏儒症及舍雷舍夫斯基-特纳综合征患者进行了弓形虫病检查。弓形虫病的诊断是根据流行病学和产科病史、临床及X线检查资料、血清学试验（两种改良的补体结合试验——常规法和微量法；沉淀试验、荧光抗体试验）以及用弓形虫素进行的皮内过敏试验（ATT）来确定的。在48例脑垂体性侏儒症患者中，17例（35.4%）ATT试验呈阳性；在7例舍雷舍夫斯基-特纳综合征患者中，3例呈阳性。在一些患者及其母亲中，弓形虫病的血清学试验也呈阳性。因此，在所检查的患者中，弓形虫病感染的发生率比健康儿童中的相应指标高2.5至3倍。据推测，在弓形虫病和侏儒症中存在下丘脑对垂体功能调节的病理改变。不能排除母体弓形虫病中生殖器官的病理改变导致染色体胚胎病发生的可能性。作者认为，有必要进一步研究以确定（在某些病例中）弓形虫病与生长发育障碍之间的病因学关联。
