形态发生信息存在于细胞外基质中：从实验室到临床的生物技术。
Morphogenetic messages are in the extracellular matrix: biotechnology from bench to bedside.
作者信息
Reddi A H
机构信息
Center for Tissue Regeneration and Repair and Department of Orthopaedic Surgery, University of California, Davis, Medical Center, Sacramento, CA 95817, USA.
出版信息
Biochem Soc Trans. 2000;28(4):345-9.
The origin and evolution of multicellular metazoa was accompanied by the appearance of extracellular matrix. The demineralized extracellular matrix of bone is enriched in morphogenetic proteins that induce bone. Bone morphogenetic proteins (BMPs) are intimately bound to collagens. BMP-4 has high affinity for type-IV collagen, and other binding proteins such as noggin and chordin. Soluble morphogens are kept in the solid state by extracellular matrix. In this sense Nature used the principles of affinity matrices long before humans patented the principle of affinity chromatography.
多细胞后生动物的起源和进化伴随着细胞外基质的出现。骨的脱矿细胞外基质富含诱导骨形成的形态发生蛋白。骨形态发生蛋白（BMPs）与胶原蛋白紧密结合。BMP-4对IV型胶原以及其他结合蛋白如头蛋白和脊索蛋白具有高亲和力。可溶性形态发生素通过细胞外基质保持固态。从这个意义上说，早在人类获得亲和色谱原理的专利之前，自然界就已经运用了亲和基质的原理。
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