Gerlach J, Thorsen K, Fog R
Psychopharmacologia. 1975;40(4):341-50. doi: 10.1007/BF00421473.
8 male schizophrenic patients participated in a double-blind, cross over study of the extrapyramidal side-effects of haloperidol and clozapine (acute dystonis, Parkinsonism and tardive dyskinesia), together with their effect on homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid (CSF). Haloperidol (9 mg/day) caused Parkinsonism, reduced tardive dyskinesias and increased the HVA concentration in the CSF. Clozapine (225 mg/day) had no effect on the neurological phenomena but reduced HVA and 5-HIAA concentrations in the CSF. During the discontinuation phase following the administration of haloperidol, tardive dyskinesia occurred or was aggravated; this did not occur after administration of clozapine. Accordingly, it is suggested that clozapine does not induce dopaminergic hypersensibility and, therefore, will not induce tardive dyskinesias.
8名男性精神分裂症患者参与了一项双盲交叉研究，该研究旨在探讨氟哌啶醇和氯氮平的锥体外系副作用（急性肌张力障碍、帕金森症和迟发性运动障碍），以及它们对脑脊液中高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）的影响。氟哌啶醇（9毫克/天）导致帕金森症，减少迟发性运动障碍，并增加脑脊液中HVA的浓度。氯氮平（225毫克/天）对神经现象无影响，但降低了脑脊液中HVA和5-HIAA的浓度。在停用氟哌啶醇后的停药阶段，迟发性运动障碍出现或加重；而在使用氯氮平后未出现这种情况。因此，有人认为氯氮平不会诱发多巴胺能超敏反应，因此也不会诱发迟发性运动障碍。
